Methods for the treatment of osteoporosis using bisphosphonates

Details Methods for the treatment of osteoporosis using bisphosphonates Methods for the treatment of osteoporosis using bisphosphonates

1996-03-20

1997-04-01

Schain, Howard S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, C07K 100, A61K 3827, A61K 3800

Patent

active

056165609

ABSTRACT:
The present invention provides methods of increasing bone mass in a human or other animal subject afflicted with osteoporosis, comprising a thirty(30)-day treatment period, comprised of a parathyroid hormone administration regimen and a bisphosphonate administration regimen, wherein

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patent: 4833125 (1989-05-01), Neer
Hesch, R. D. et al., "Results of a Stimulatory Therapy of Low Bone Metabolism in Osteoporosis with (1-38) hPTH and Diphosphonate EHDP-Protocol of Study I, Osteoporosis Trial Hannover" 66(19) Klin Wschr. 976-984 (Oct. 1988).
Delling, G., et al., "Morphologic Study of Pelvic Crest Spongiosa in Patients with Osteoporosis During ADFR Therapy with Parathyroid Hormone and Diphosphonates", 128(1) Z. Orthop. 1-5 (1990).
Delmas, et al., "The In Vivo Anabolic Effect of hPTH-(1-34) is Blunted When Bone Resorption Is Blocked By a Bisphosphonate", 6 (Supp. 1) J. Bone Mineral Res. .sctn.136 (Abst. 214) (Aug. 1991).
Hock, et al., "Resorption Is Not Essential for the Stimulation of Bone Growth by hPTH-(1-34) In Rats In Vivo", 4(3) J. Bone Mineral Res 449-458 (1989).

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