Methods for the treatment of demyelinating disease, uveitis, or

Details Methods for the treatment of demyelinating disease, uveitis, or Methods for the treatment of demyelinating disease, uveitis, or

1991-03-07

1993-03-02

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

514 12, 514 21, A61K 3702

Patent

active

051907500

ABSTRACT:
A pharmaceutical composition and a method for its use in the treatment of severe chronic inflammatory diseases, such as demyelinating disease, uveitis and graft-versus-host disease are provided. The composition comprises tumor necrosis factor as an active ingredient and at least one pharmaceutically acceptable carrier, diluent or excipient.

REFERENCES:
patent: 4963354 (1990-10-01), Shepard et al.
Cancer Immunology Immunotherapy, 27, 103-108 (1989), Ehrke et al.
Chem-Abstracts, vol. 110, 1989, 13581e, Nakamura et al. (1989).
Piguet et al., J. Exp. Med. 166, 1280-1289 (1987).
Kulkarni et al. Exp. Eye Res. 46, 631-633 (1988).
Shalaby et al. Transplantation 47, 1057-1061 (1989).
Selmaj et al. The Journal of Imunpology 144 129-135 (1990).
Paya et al. International Immunology 2(9), 909-913 (1990).

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