Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-08-28
1998-11-03
Marschel, Ardin H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
436501, 514 44, 935 88, A61K 4800
Patent
active
058308504
ABSTRACT:
The present invention relates to methods and compositions for the amelioration of symptoms caused by bone resorption disorders, including but not limited to osteoporosis, arthritides and periodontal disease, and damage caused by macrophage-mediated inflammatory processes. In one embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K activity. In an additional embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K activity coupled with specific inhibition of at least a second activity involved in the bone resorption and/or macrophage-mediated inflammatory processes. In a particular embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K and cathepsin S activity.
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Chapman Harold
Desnick Robert J.
Gelb Bruce D.
Brigham and Women's Hospital
Marschel Ardin H.
Mount Sinai School Of Medicine Of The City of New York
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