Methods for the treatment and prevention of pancreatitis and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C514S673000

Reexamination Certificate

active

10731626

ABSTRACT:
Novel methods for treating and preventing acute and/or chronic pancreatitis are described. Additionally, novel methods for inducing liver regeneration are described. The methods may comprise administering to a patient an effective amount of a metabolically stable analogue of spermidine and/or spermine. Preferred compounds for use in the methods may include 1-methylspermidine, 1-methylspermine and 1,12-dimethylspermine.

REFERENCES:
patent: 4330559 (1982-05-01), Bey et al.
patent: 5171754 (1992-12-01), Lau
patent: 5242947 (1993-09-01), Cherksey et al.
patent: 5254572 (1993-10-01), Serfontein
patent: 5344846 (1994-09-01), Jakus et al.
patent: 5462970 (1995-10-01), Bergeron et al.
patent: 5498522 (1996-03-01), Porter
patent: 5516807 (1996-05-01), Hupe et al.
patent: 5541230 (1996-07-01), Basu et al.
patent: 6060471 (2000-05-01), Styczynski et al.
patent: 6342534 (2002-01-01), Bergeron, Jr.
patent: 7030126 (2006-04-01), Ramesh et al.
patent: 2003/0143713 (2003-07-01), Aghajari et al.
patent: WO 200147528 (2001-07-01), None
(“Pancreatitis: Advances in Pathobiology, Diagnosis and Treatment”, Barbu, S.T., Symposium Report, Oct. 14-15, 2004.
“Chronic Pancreatitis”, www.patient.co.uk, 2004.
“Hereditary Pancreatitis”, www. pancreasfoundation.org, 2004.
Alhonen, L., et al., “Polyamines are required for the initiation of rat liver regeneration,”Biochem. J., 2002, 362, 149-153.
Alhonen, L., et al., “Activation of polyamine catabolism in transgenic rats induces acute pancreatitis,”J. Proc. Natl. Acad. Sci. USA, Jul. 18, 2000, 97(15), 8290-8295.
Bernacki, R.J., et al., “Antitumor activity ofN,N'-Bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts,”Cancer Res., May 1, 1992, 52, 2424-2430.
Bernacki, R.J., et al., “Preclinical antitumor efficacy of the polyamine analogueN1'N11-diethylnorspermine administered by multiple injection or continuous infusion,”Clin. Cancer Res., Aug. 1995, 1, 847-848.
Bolkenius, F.N., et al., “Specific inhibition of polyamine oxidase in vivo is a method for the elucidation of its physiological role,”Biochim. Biophys. Acta, 1985, 838, 69-76.
Casero, R.A., et al., “Spermidine/spermine N1-acetyltransferase—the turning point in polyamine metabolism,”FASEB J., 1993, 7, 653-661.
Greene, T.W., et al., P.G.M., Protective Groups in Organic Synthesis, 3rdEd.,Wiley&Sons, 1999.
Hakovirta, H., et al., “Polyamines and regualtion of spermatogenesis: selective stimulation of late spermatogonia in transgenic mice overexpressing the human ornithine decarboxylase gene,”Mol. Endocrinol., 1993, 7, 1430-1436.
Halmekytö, M., et al., “Transgenic mice over-producing putrescine in their tissues do not convert the diamine into higher polyamines,”Biochem. J., 1993, 291, 505-508.
Halmekytö, M., et al., “Transgenic mice aberrantly expressing human ornithine decarboxylase gene,”J. Biol. Chem., Oct. 15, 1991, 266(29), 19746-19751.
Higgins, G.H., et al., “Experimental pathology of the liver,”Arch. of Pathol., Jan. 20, 1931, 12, 186-202.
Hölttä, E., “Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase,”Biochemistry, 1977, 16(1), 91-100.
Hyvönen, T., et al., “Monitoring of the uptake and metabolism of aminooxy analogues of polyamines in cultured cells by high-performance liquid chromatography,”J. of Chromatogr., 1992, 574, 17-21.
Imrie, C.W., et al., “A prospective study of acute pancreatitis,”Br. J. Surg., 1975, 62, 490-494.
Jacobs, M.L., et al., “Acute pancreatitis: Analysis of factors influencing survival,”Ann. Surg., 1977, 185, 43-51.
Jänne, J., et al., “Polyamines: from molecular biology to clinical applications,”Ann. Of Med., 1991, 23, 241-259.
Jänne, J., et al., “On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme,”J. Biol. Chem., Mar. 25, 1971, 246(6), 1725-1732.
Khomutov, A.R., et al., “Synthesis of hydroxylamine analogues of polyamines,”Tetrahedron, 1996, 52(43), 13751-13766.
Kumazawa, T., et al., “A radioisotopic assay for polyamine oxidase,”Anal Biochem, 1990, 188, 105-108.
Lakanen, J.R., et al., “α-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines,”J. Med. Chem., 1992, 35, 724-734.
Leach, S.D., et al., “New perspectives on acute pancreatitis,”Scan J. Gastroenterol, 1992, 27 (Suppl. 192), 29-38.
Lukkarinen, J., et al., “Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion,”Stroke, 1997, 28, 639-645.
Nagarajan, S., et al., “Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to α- difluoromethylornithine,”Biochem. J., 1988, 254, 373-378.
Nagarajan, S., et al., “Chemistry of naturally occurring polyamines. 10.1Nonmetabolizable derivatives of spermine and spermidine,”J. Org. Chem., 1986, 51, 4856-4861.
Niederau, C., et al., “Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice,”J. Clin. Invest., 1986, 78, 1056-1063.
Pietilä, M., et al., “Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase,”J. Biol. Chem., Jul. 25, 1997, 272, 18746-18751.
Räsänen, T.L., et al., “A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism,”J. Biol. Chem., Oct. 18, 2002, 277(42), 39867-39872.
Remington's Pharmaceutical Sciences,Mack Pub. Co., 1980.
Steinberg, W., et al., “Acute pancreatitis,”N. Eng. J. Med., Apr. 28, 1994, 330, 1198-1210.
Suppola, S., et al., “Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein 1 promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue,”Biochem. J., 1999, 338, 311-316.
Suppola, S., et al., “Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N1-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice,”Biochem. J., 2001, 358, 343-348.
Vujcic, S., et al., “Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion,”Biochem. J., 2003, 370, 19-28.
Vujcic, S., et al., “Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin,”Biochem. J., 2002, 367, 665-675.
Wang, Y., et al., “Properties of purified recombinant human polyamine oxidase, PAOh1/SMO,”Biochem. Biophys. Res. Commun., 2003, 304, 605-611.
Wu, T., et al., “Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase,” J.Biol. Chem., Jun. 6, 2003, 278(23), 20514-20525.

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