Methods for the synthesis of phosphonate esters

Details Methods for the synthesis of phosphonate esters Methods for the synthesis of phosphonate esters

1993-09-09

1995-05-30

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

C07F 909

Patent

active

054203287

ABSTRACT:
Phsophonate esters can be synthesized in high yields by condensations of alcohols with methyl phosphonates followed by selective demethylation. The reaction is general, relativly insensitive to steric constraints of hindered phosphonic acids, and can also be carried out on a solid support to synthesize large collections of compounds to screen for pharmacological activity.

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