Methods for the synthesis of phosphonate esters

Details Methods for the synthesis of phosphonate esters Methods for the synthesis of phosphonate esters

1992-09-11

1994-10-25

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558108, C07F 940

Patent

active

053591151

ABSTRACT:
Phosphonate esters can be synthesized in high yields by condensations of alcohols with methyl phosphonates followed by selective demethylation. The reaction is general, relatively insensitive to steric constraints of hindered phosphonic acids, and can also be carried out on a solid support to synthesize large collections of compounds to screen for pharmacological activity.

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