Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1992-07-14
1994-12-20
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514 54, 514567, 514 53, 530403, 536116, 536 53, 435238, 435193, A01N 3712, A01N 3744, C07H 1504, C12N 706
Patent
active
053746554
ABSTRACT:
Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound .beta.Gal(1-4).beta.GlcNAc(1-3).beta.Gal(1-4).beta.GlcNAc-OR. In particular, the methods of this invention provide for a multi-step synthesis wherein selective monofucosylation is accomplished on the 3-hydroxy group on only one of the GlcNAc units found in the .beta.Gal(1-4) .beta.GlcNAc (1-3) .beta.Gal (1-4) .beta.GlcNAc-OR compound. In this step, monofucosylation is achieved by use of the .alpha.(1-3)fucosyltransferase.
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Kashem Mohammed
Smith Richard
Venot Andre P.
Alberta Research Council
Leary Louise N.
Russel Jeffrey E.
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