Methods for the synthesis of monofucosylated oligosaccharides te

Details Methods for the synthesis of monofucosylated oligosaccharides te Methods for the synthesis of monofucosylated oligosaccharides te

1994-10-14

1996-08-27

Kight, III, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514 54, 514 53, 514567, 530402, 536 53, 536116, 5361231, 53612313, 435238, 435193, 435195, A01N 4740, C08B 3700, C07K 100, C12N 706

Patent

active

055501559

ABSTRACT:
Monofucosylated and monosialyated derivatives of the compound .beta.Gal(1-4).beta.GlcNAc(1-3).beta.Gal(1-4).beta.GlcNAc-OR, where R is hydrogen, a saccharide, an oligosaccharide or an aglycon moiety have been found to be useful in modulating a cell-mediated immune inflammatory response in mammals.

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patent: 5079353 (1992-01-01), Ratcliff et al.
patent: 5374655 (1994-12-01), Kashem et al.
Gross et al; Biochem (1989) vol. 28 pp. 7386-7392.
Paulsen, Hans; Agnew Chem. Int Ed. Engl. 21(1982) pp. 155-173.
Schauer et al; "Sialic Acids"; 1988, pp. 20-21.
Okamoto et al; Tetrahedron vol. 46, No. 17, pp. 5835-5857 (1990).
Reuter et al; Glycoconjugate Jour, (1988) 5: pp. 133-135.

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