Methods for the synthesis of milnacipran and congeners thereof

Details Methods for the synthesis of milnacipran and congeners thereof Methods for the synthesis of milnacipran and congeners thereof

2007-12-18

2007-12-18

Puttlitz, Karl (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S461000

Reexamination Certificate

active

11097466

ABSTRACT:
One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

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Shuto, S. et al., “Synthesis of (+)- and (−)-Milnaciprans and Their Conformationally Restricted Analogs”,Tetrahedron Letters, 37(5):641-644 (1996).
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International Search Report issued for corresponding PCT application No. PCT/US2005/011365 dated Feb. 2, 2006.

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