Methods for the synthesis of arrays of DNA probes

Details Methods for the synthesis of arrays of DNA probes Methods for the synthesis of arrays of DNA probes

2006-09-20

2011-10-04

Forman, Betty (Department: 1634)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C435S283100, C435S288700, C422S068100, C422S082050, C359S298000

Reexamination Certificate

active

08030477

ABSTRACT:
The synthesis of arrays of DNA probes sequences, polypeptides, and the like is carried out using a patterning process on an active surface of a substrate. An image is projected onto the active surface of the substrate utilizing reflective projection optics. The projection optics project a light image onto the active surface of the substrate to deprotect linker molecules thereon. A first level of bases may then be applied to the substrate, followed by development steps, and subsequent exposure of the substrate utilizing a different light image, with further repeats until the elements of a two dimensional array on the substrate surface have an appropriate base bound thereto.

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