Methods for the synthesis of alfentanil, sufentanil, and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

11362498

ABSTRACT:
Synthetic pathways are disclosed for synthesizing derivatives or analogs of fentanyl. Specifically set out are pathways for synthesizing alfentanil, sufentanil and remifentanil. The disclosed methods require fewer steps and produce a greater yield of product than methods reported in the prior art.

REFERENCES:
patent: 3161644 (1964-12-01), Janssen et al.
patent: 3998834 (1976-12-01), Janssen et al.
patent: 4167574 (1979-09-01), Janssens
patent: 5019583 (1991-05-01), Feldman et al.
patent: 5489689 (1996-02-01), Mathew
patent: 1 598 872 (1981-09-01), None
patent: WO 95/09152 (1995-04-01), None
patent: WO 95/09155 (1995-04-01), None
Borne, Ronald F. et al., Conformationally Restrained Fentanyl Analogues . . . , J. Med. Chem., 1984, pp. 1271-1275.
Kudzma, Linas V. et al., 4-Phenyl- and 4-Heteroaryl-4-anilidopiperidines . . . , J. Med. Chem., 1989, pp. 2534-2542.
Colapret, John A. et al., Synthesis and Pharmacological Evaluation of 4,4-Disubstituted Piperidines, J. Med. Chem., 1989, pp. 968-974.
Feldman, Paul L. et al., Design, Synthesis, and Pharmacological Evaluation of . . . , J. Med. Chem., 1991, pp. 2202-2208.
Amin, Hesham M. et al., Naloxone-Induced and Spontaneous Reversal of Depressed . . . , J. Pharmacol. Exp. Ther., 1995, pp. 34-39.
Drugs of Today, New Products, 1984, pp. 7-13, vol. 20 (1).
Bower, S. and Hull, C.J., Comparative Pharmacokinetics of Fentanyl and Alfentanil, Brit. J. Anaesth., 1982, pp. 871-887.
Stanski, Donald and Hug Jr, Carl C., Alfentanil-A Kinetically Predicatble Narcotic Analgesic, J. of Anesthesiology, 1982, pp. 435-438.
Sinclair, M.E. and Cooper, G.M., Alfentanil and recovery, Anaesthesia, 1983, pp. 435-437.
Noorduin, Henk et al., Alfentanil Infusions for Peroperative and Postoperative Analgesia, Drug Dev. Res., 1986, pp. 347-352.
Niemegeers, C.J. et al., Sufentanil, a very Potent and extremely Safe Intravenous Morphine-like . . . , Arzneim. Forsch. 1976, pp. 1551-1556, vol. 27, Nr. 8.
Gassman et al., Base-Promoted Hydrolysis of Amides . . . , J. Am. Chem. Soc., 1976, pp. 1275-1276, vol. 98:5.
Janssens, F. et al., Synthetic 1,4-Disubstituted-1,4-dihydro-5H-tetrazol . . . , J. Med. Chem., 1985, pp. 2290-2297, vol. 29:11 (From Search Report dated May 17, 2001).
Meuldermans, J. et al., Excretion and Biotransformation of Alfentanil . . . , Drug Metabolism and Disposition, 1987, pp. 905-913, vol. 15:6 (From Search Report dated May 17, 2001).
Arzeno, Humberto B. et al., Synthese De La 10(S)-Methyl-codeine Et De La . . . , Institut de Chimie, 1980, pp. 369-375.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for the synthesis of alfentanil, sufentanil, and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the synthesis of alfentanil, sufentanil, and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the synthesis of alfentanil, sufentanil, and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3753410

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.