Methods for the specific preparation of lysobactin fragments

Details Methods for the specific preparation of lysobactin fragments Methods for the specific preparation of lysobactin fragments

2007-05-04

2010-06-15

Kosar, Andrew D (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S328000, C424S094640

Reexamination Certificate

active

07737120

ABSTRACT:
The invention relates to methods for the targeted production of lysobactin derivatives by combined chemical and enzymatic modifications. In particular, the invention relates to method for preparing lysobactin fragment 4-11 by chemical reduction and cleavage of the resultant product by chymotrypsin.

REFERENCES:
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Blackburn et al., Drug Metab. Dispos. (1993) 21(4):573-579.
Bonner et al., J. Antibiot. (1988) 41:1745-1751.
Cardillo et al., Eur. J. Org. Chem. (2000) 2489-2494.
International Search Report for PCT/EP2005/011364, Mailed on Jan. 26, 2006, 5 pages.
Palomo et al., Pure Appl. Chem. (2000) 72(9):1763-1768.
Palomo et al., Tetrahedron Letters (2001) 42:8955-8957.
O'Sullivan et al., J. Antibiot. (1988) 41-1740-1744.
Tymiak et al., J. Org. Chem. (1989) 54:1149-1157.
English translation of the International Preliminary Report on Patentability for PCT/EP2005/011364, mailed Jul. 12, 2007, 8 pages.

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