Methods for the selective modification of viral nucleic acids

Details Methods for the selective modification of viral nucleic acids Methods for the selective modification of viral nucleic acids

1997-05-13

2000-10-24

Wortman, Donna C.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

435 2, C12N 706, A01N 102

Patent

active

061365866

ABSTRACT:
This invention provides means and methods of inactivating viruses and other organisms in cell-containing or biopolymer-containing compositions without significant alteration of proteins or other biopolymers by contacting such compositions with selective ethyleneimine oligomer inactivating agents, such as the trimer or tetramer.

REFERENCES:
patent: 3492289 (1970-01-01), Symm et al.
patent: 4036952 (1977-07-01), Bauer et al.
patent: 4058599 (1977-11-01), Bauer et al.
patent: 4841023 (1989-06-01), Horowitz
patent: 5000951 (1991-03-01), Bass et al.
patent: 5055485 (1991-10-01), Geacintov et al.
patent: 5120649 (1992-06-01), Horowitz et al.
patent: 5232844 (1993-08-01), Horowitz et al.
patent: 5374424 (1994-12-01), Kelsey et al.
patent: 5559250 (1996-09-01), Cook et al.
Murphy, "Virus Taxonomy", pp. 15-57 in Fields et al., Fields Virology, Lippincott-Raven, Philadelphia, 1996.
Creech et al., "Antitumor and Mutagenic Properties of a Variety of Heterocyclic Nitrogen and Sulfur Mustards," Medicinal Chemistry, 15: 739-746, 1972.
International search report for PCT/US96/14040 mailed Jan. 14, 1997.
International preliminary examination report for PCT/US96/14040 mailed Dec. 9, 1997, 6 pages.
Bahnemann, H.G., "Inactivation of Viruses in serum with Binary Ethyleneimine", Journal of Clinical Microbiology, vol. 3, No. 2, pp. 209-210 (1975).
Bahnemann, H.G., "Inactivation of Viral Antigens for Vaccine Preparation with Particular Reference to the Application of Binary Ethylenimine", Vaccine, 8:299-303 (1990).
Budowsky et al., "Inactivation of the phage MS2 infectivity by the action of ethyleneimines," Biorg. Khim. 11:989-991 (1985) (in Russian). English Abstract provided, 1 page.
Budowsky, E.I. and Zalesskaya, M.A., "Principles of selective inactivation of viral genome. v. Rational selection of conditions for inactivation of the viral suspension infectivity to a given extent by the action of B-propiolactone," Vaccine 9:319-325 (1991).
Budowsky, E.I. et al., "Principles of Selective Inactivation of the Viral Genome; Dependence of the Rate of Viral RNA Modification on the Number of Protonizable Groups in Ethyleneimine Oligomer", Vaccine Research, 5(1):29-39 (1996).
Dermer, O.C. and Ham, G.E. Ethyleneimine And Other Aziridines, Acad. Press, NY-London (1969), pp. 249-285.
Earley, J.E et al., "Reactions of Ethylenimines. IX. The Mechanisms of Ring Openings of Ethylenimines in Acidic Solutions," J. Am Chem. Soc. 80:3458-3462 (1958).
King, "Evaluation of Different Methods of Inactivation of Newcastle Disease Virus and Avian Influenza Virus in Egg Fluids and Serum," Avian Diseases 35:505-514 (1991).
Kochetkov, N.K. and Budowsky, E.I. eds., Organic Chemistry of Nucleic Acids, Part A, Plenum Press, London-New York, pp. 48-55, (1972).
Kostyanovskii et al., "Oligomers of azridines and N-beta-azridinoethylamides," Bulletin of Academy of Sciences of the USSR, Division of Chemical Science vol. 37(11):2315-2325, May 20, 1989. (Translated from IzvestiyaAkademi Nauk SSSR, Seriya Khimicheskaya 11:2566-2575).
Prodouz et al., "Inhibition of Merocyainine 540-mediated Photosensitization of Platelets and Viruses," Transfusion 31:415-422 (1991).
Race, E. et al., "An Experimental Chemically Inactivated HIV-1 Vaccine induces Antibodies that Neutralize Homologous and Heterologous Viruses", Vaccine, 13(1):.54-60 (1995).
Tanirbergenov, T.B. et al., "Regularities of mutagenic and toxic effects of ethyleneimine and its oligomers. A comparative study in the automated system SOS-chromotest and in standard bacterial test systems," Genetika 24:763 (1998) (in Russian). English translation provided, 5 pages.
Van Etten,, R.L. and Dolhum, J.J., "Effects of Hydrogen-Bond Formation by Phenols on the Conformational Equilibrium of trans-1,2-Dimethyl-3-isopropylaziridine," J. Org. Chem. 33:3904-3907 (1968).
Wagner et al., "Approaches to the Reduction of Viral Infectivity in Cellular Blood Components and Single Donor Plasma," Transfusion Med. Rev. V:18-32 (1991).

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