Multicellular living organisms and unmodified parts thereof and – Method of introducing a polynucleotide molecule into or... – Via agrobacterium
Reexamination Certificate
2005-08-30
2005-08-30
McElwain, Elizabeth F. (Department: 1638)
Multicellular living organisms and unmodified parts thereof and
Method of introducing a polynucleotide molecule into or...
Via agrobacterium
C800S288000, C800S306000, C800S278000, C536S023100, C435S320100, C435S419000
Reexamination Certificate
active
06936747
ABSTRACT:
The present invention includes compositions and methods for site-specific polynucleotide replacement in eukaryotic cells. These methods include single polynucleotide replacement as well as gene stacking methods. Preferred eukaryotic cells for use in the present invention are plant cells and mammalian cells.
REFERENCES:
patent: 5190871 (1993-03-01), Cox et al.
patent: 5527695 (1996-06-01), Hodges et al.
patent: 5744336 (1998-04-01), Hodges et al.
patent: 5910415 (1999-06-01), Hodges et al.
patent: 6110736 (2000-08-01), Hodges et al.
patent: 6114600 (2000-09-01), Ow et al.
patent: 6175058 (2001-01-01), Baszczynski et al.
patent: 6187994 (2001-02-01), Baszczynski et al.
patent: 6262341 (2001-07-01), Baszczynski et al.
patent: 6632672 (2003-10-01), Calos
patent: 6746870 (2004-06-01), Ow et al.
patent: 99/25821 (1999-05-01), None
patent: PCT/US99/18987 (1999-08-01), None
patent: PCT/US00/09154 (2000-04-01), None
patent: PCT/US00/19983 (2000-07-01), None
(Buchanan, et al. Biochemistry & Molecular Biology of Plants (2000) American Society of Plant Physiologists, Rockville Md 20855, p. 322, last paragraph).
Ow, David W., “Recombinase-directed plant transformation for the post-genomic era”, Plant Molecular Biology, 48:183-200 (2002).
Albert et al., Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome, 1995 Plant J., 7:649-59.
Alonso et al., TheBacillus subtilisHistone-like Protein Hbsu Is Required for DNA Resolution and DNA Inversion Mediated by the β Recombinase of Plasmid pSM19035, 1995 J. Biol. Chem., 270:2938-45.
Araki, H. et al., Site-specific Recombinase, R, Encoded by Yeast Plasmid pSR1, 1992 J. Mol. Biol., 225(1):25-37.
Araki, K. et al., Targeted integration of DNA using mutant lox sites in embryonic stem cells, 1997 Nucleic Acids Res., 25:868-72.
Argos et al., The integrase family of site-specific recombinases: regional similarities and global diversity, 1986 The EMBO J., 5:433-40.
Bannam et al., Molecular genetics of the chloramphenicol-resistance transposon Tn4451 fromClostridium perfringens: the TnpX site-specific recombinase excises a circular transposon molecule, 1995 Mol. Microbiology, 16:535-51.
Battacharyya et al., Reduced variation in transgene expression from a binary vector with selectable markers at the right and left T-DNA borders, 1994 Plant J., 6:957-68.
Baubonis and Sauer, Genomic targeting with purified Cre recombinase, 1993 Nucl. Acids Res., 21:2025-29.
Bayley et al., Exchange of gene activity in transgenic plants catalyzed by the Cre-lox site-specific recombination system, 1992 Plant Mol. Biol., 18:353-61.
Bethke and Sauer, Segmental genomic replacement by Cre-mediated recombination: genotoxic stress activation of the p53 promoter in single-copy transformants, 1997 Nucleic Acids Res., 25: 2828-34.
Carrasco et al.,Anabaena xisFgene encodes a developmentally regulated site-specific recombinase, 1994 Genes & Development, 8:74-83.
Choi et al., A new approach for the identification and cloning of genes: the pBACwich system using Cre/lox site-specific recombination, 2000 Nucl. Acids Res., 28:e19(i-vii).
Corneille et al., Efficient elimination of selectable marker genes from the plastid genome by the CRE-lox site-specific recombination system, 2001 The Plant J., 27:171-78.
Crellin and Rood, The Resolvase/Invertase Domain of the Site-Specific Recombinase TnpX Is Functional and Recognizes a Target Sequence That Resembles the Junction of the Circular Form of theClostridium perfringensTransposon Tn4451, 1997 J. of Bacteriology, 179:5148-56.
Crisona, N.J. et al., Processive Recombination by Wild-type Gin and an Enhancer-independent Mutant, 1994 J. Mol. Biol., 243(3):437-57.
Dale and Ow, Gene transfer with subsequent removal of the selection gene from the host genome, 1991 Proc. Natl. Acad. Sci., 88:10558-62.
Dale and Ow, Intra- and intermolecular site-specific recombination in plant cells mediated by bacteriophage P1 recombinase, 1990 Gene 91:79-85.
Davies et al., Somatic and germinal inheritance of an FLP-mediated deletion in transgenic tobacco, 1999 J. of Experimental Botany, 50:1447-56.
Day et al., Transgene integration into the same chromosome location can produce alleles that express at a predictable level, or alleles that are differentially silenced, 2000 Genes & Development, 14:2869-80.
De Buck et al., Transgene silencing of invertedly repeated transgenes is released upon deletion of one of the transgenes involved, 2001 Plant Mol. Biol, 46:433-45.
Diaz et al., The Prokaryotic β-Recombinase Catalyzes Site-specific Recombination in Mammalian Cells, 1999 J. Biol. Chem., 274:6634-6640.
Diaz et al., New Insights into Host Factor Requirements for Prokaryotic β-Recombinase-mediated Reactions in Mammalian Cells, 2001 J. Biol. Chem., 276:16257-64.
Feng et al., Site-specific Chromosomal Integration in Mammalian Cells: Highly Efficient CRE Recombinase-mediated Cassette Exchange, 1999 J. Mol. Biol., 292:779-85.
Finkel and Johnson, The Fis protein: it's not just for DNA inversion anymore, 1992 Mol. Microbiology, 6:3257-65.
Friedman, Integration Host Factor: A Protein for All Reasons, 1988 Cell, 55:545-54.
Gleave et al., Selectable marker-free transgenic plants without sexual crossing: transient expression of cre recombinase and use of a conditional lethal dominant gene, 1999 Plant Mol. Biol., 40:223-35.
Groth et al., A phage integrase directs efficient site-specific integration in human cells, 2000 PNAS, 97:5995-6000.
Hajdukiewicz et al., Multiple pathways for Cre/lox-mediated recombination in plastids, 2001 The Plant J., 27:161-170.
Hatfull and Grindley, Resolvases and DNA-Invertases: a Family of Enzymes Active in Site-Specific Recombination, 1988 Genetic Recombination, 11:357-96.
Hohn et al., Elimination of selection markers from transgenic plants, 2001 Current Opinion in Biotechnology, 12:139-43.
Howe et al., Cis-Effects of Heterochromatin and Euchromatic Gene Activity inDrosophila melanogaster, 1995 Genetics, 140:1033-45.
Iyer et al., Transgene silencing in moncots, 2000 Plant Mol. Biol., 43:323-46.
Kaeppler et al., Epigenetic aspects of somaclonal variation in plants, 2000 Plant Mol. Biol., 43:179-88.
Kilby et al., Controlled induction of GUS marked clonal sectors inArabidopsis, 2000 J. of Experimental Botany, 51:853-63.
Kolb and Siddell, Genomic targeting of a bicistronic DNA fragment by Cre-mediated site-specific recombination, 1997, Gene, 203:209-16.
Kolot et al., Site-specific recombination in mammalian cells expressing the Int Recombinase of bacteriophage HK022, 1999 Mol. Biol. Reports, 26:207-13.
Kuhstoss and Rao, Analysis of the Integration Function of the Streptomycete Bacteriophage ΦC31, 1991 J. Mol. Biol., 222:897-908.
Kutsukake K. et al., A gene for DNA invertase and an invertible DNA inEscherichia coliK-12, 1985 Gene, 34(2-3):343-50.
Landy, Dynamic, Structural, and Regulatory Aspects of λ Site-Specific Recombination, 1989 Annu. Rev. Biochem., 58:913-49.
Loessner et al., Complete nucleotide sequence, molecular analysis and genome structure of bacteriophage A118 ofListeria monocytogenes: implications for phage evolution, 2000 Mol. Microbiology, 35:324:40.
Loonstra et al., Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells, 2001 PNAS, 98:9209-14.
Lorbach et al. Site-specific Recombination in Human Cells Catalyzed by Phage λ Integrase Mutants, 2000 J. Mol. Biol., 296:1175-81.
Lyznik, L.A. et al., FLP-mediated recombination of FRT sites in the maize genome,1996 Nucleic Acids Res., 24(19):3784-9.
Lyznik, L.A. et al., Activity of yeast FLP recombinase in maize and rice protoplasts, 1993 Nucleic Acids Res., 21:969-75.
Maeser and Kahmann, The Gin recombinase of phage Mu can catalyse site-specific recombination in plant protoplasts, 1991 Mol. Gen. Genet., 230:170-76.
Matsuura et al., The sre Gene (ORF469) Encodes a Site-Specific Recombinase Responsible for Integration of the R4 Phage Genome, 1996 J. of Bacteriology, 178:3374-76.
Matzke et al., Transgene silencing by the host genome defense: implications for the evolution of epigenetic
Connor Margaret A.
Helmer Georgia
McElwain Elizabeth F.
Sutherland & Asbill & Brennan LLP
The United States of America as represented by the Secretary of
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