Methods for the purification of levofloxacin

Details Methods for the purification of levofloxacin Methods for the purification of levofloxacin

2002-11-27

2008-09-16

Habte, Kahsay T (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C544S099000

Reexamination Certificate

active

07425628

ABSTRACT:
The invention provides a process for preparing levofloxacin hemihydrate, comprising:(A) dissolving levofloxacin in a solvent selected from the group consisting of acetonitrile, acetonitrile:H2O, dimethyl sulfoxide, dimethyl sulfoxide:H2O, methyl ethyl ketone, methyl ethyl ketone:H2O, butanol, butanol:H2O, and mixtures thereof at an elevated temperature; and(B) crystallizing levofloxacin hemihydrate.

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