Methods for the production of antibodies and induction of immune

Details Methods for the production of antibodies and induction of immune Methods for the production of antibodies and induction of immune

1994-11-03

1996-03-19

Kim, Kay K. A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Cancer cell or component thereof

4241741, 4241841, 5303888, 53038885, 530866, A61K 3170, A61K 4505

Patent

active

055002153

ABSTRACT:
The present invention relates to an improved method for the production of antibodies to tumor-associated gangliosides using ganglioside lactones. The resulting antibodies are useful in the detection and treatment of tumors containing gangliosides. The present invention also relates to methods of treatment of tumors by active immunization using ganglioside lactones.

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patent: 4904596 (1990-02-01), Hakomori
patent: 5308614 (1994-05-01), Hakomori
Livingstone, P. O., et al., PNAS 84:2911-2915, (May 1987) "Vaccines containing purified Gmz ganglioside elicit GM2 antibodies in wiedkuroma patients".
Hakomori, S., et al. in vol. 1 Immunochemistry (1986) Chap. 9 pp. 9.1-9.39. "Carbohydrate antigens in higher animals".
Kohler G. et al., Nature 256:495-497 (1975) "Continuous cultures of fused cells secreting antibody of predefined specificity".
Fundenberg, H. H. (ed.) Basic & Clinical Immunology (1980), pp. 722-736. Lange Med. Publications.
Proc. Natl. Acad. Sci., vol. 82, pp. 1242-1246, Feb. 1985, "Mouse monoclonal IgG3 antibody detecting G.sub.D3 ganglioside: A phase I trial . . . melanoma", Alan N. Houghton et al.
The Jour. of Biological Chemistry, vol. 258, No. 19, Oct. 10, 1983, pp. 11819-11822, "A monoclonal antibody directed to N-Acetylneuraminosyl-.alpha.2.fwdarw.6-galactosyl Residue in Gangliosides . . . ", Hakomori et al.
Pukel et al., "G.sub.D3, A Prominent Ganglioside of Human Melanoma," J. Exp. Med., vol. 155, pp. 1133-1147, Apr. 1982.
Riboni et al., "Natural Occurrence of Ganglioside Lactones", J. Biol. Chem., v. 261, 8514, 1986.
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