Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1998-12-31
2000-09-12
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424 45, 424423, 424427, 424435, 424443, 424449, 424451, 424464, A61F 1302, A61F 202, A61K 948, A61K 920, A61L 904
Patent
active
061174459
ABSTRACT:
Methods of treating or preventing fibrosis and sclerosis by the administration of compositions containing A.sub.1 adenosine receptor antagonists and/or P.sub.2X purinoceptor antagonists, or combinations thereof.
REFERENCES:
patent: 5320962 (1994-06-01), Stiles et al.
patent: 5571846 (1996-11-01), Murad et al.
patent: 5604199 (1997-02-01), Funanage
patent: 5645839 (1997-07-01), Chobanian et al.
Wang et al, "Extracellular ATP and ADP stimulate proliferation of Porcine aortic Smooth Muscle Cells", J. Cell. Physiol., 153(2), 221-33, 1992.
Eidelman et al.; A.sub.1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells, Proc. Natl. Acad. Sci. USA 89:5562-5566 (1992).
Hansen et al.; The distribution of single P.sub.2x1 -receptor clusters on smooth muscle cells in relation to nerve varicosities in the rat urinary bladder, Journal of Neurocytology 27:529-539 (1998).
Spedding et al.; Developments in Purine and Pyridimidine Receptor-Based Therapeutics, Drug Development Research 39:436-441 (1996).
Ahmed et al.; Presence of Both A.sub.1 and A.sub.2a Adenosine Receptors in Human Cells and their Interaction; Biochemical and Biophysical Research Communications, 208(2):871-878 (1995).
Cook et al.; Adenosine and Adenine Nucleotides Inhibit the Autonomous and Epidermal Growth Factor-Mediated Proliferation of Cultured Human Keratinocytes, J. Invest. Dermatol, 104:976-981 (1995).
Cronstein, B.; Adenosine, an endogenous anti-inflammatory agent, J. Appl. Physiol. 76(1):5-13 1994.
Dubey et al.; Exogenous and Endogenous Adenosine Inhibits Fetal Calf Serum-Induced Growth of Rat Cardiac Fibroblasts, Circulation; 96:2656 (1997).
Ethier et al.; Adenosine stimulates proliferation of human endothelial cells in culture; Am. J. Physiol. 265(Heart Circ. Physiol. 34):H131 (1993).
Fereydoun et al.; Inhibition of TNF-alpha expression by adenosine, J. Immunology, 156:3435 (1996).
Li et al.; The Effects of LPS and probucol on interleukin 1 (IL-1) and platelet-derived growth factor (PDGF), Biochem Biophys. Acta, 1225:271 (1994).
Liao et al.; Endotoxin: Possible roles in initiation and development of atherosclerosis, J. Lab. Clin. Med., 128(5):452 (1996).
Mancini et al.; An interleukin-1 receptor antagonis decreases fibrosis induced by dimethylnitrosamine in rat liver; Virchows Archiv; 424:25-31 (1994).
Montesinos et al.; Wound healing is accelerated by Agonists of A2 Receptors, J. Exp. Med.; 186:1615 (1997).
Neely et al.; P .sub.2x purinoceptors in the feline pulmonary vascular bed: distribution and selective in vivo pharmacological probes; Am. J. Physiol; 270 (Lung Cell. Mol. Physiol.):L889-L897 (1996).
Neely et al.; A adenosine receptor antagonistsblock ischemia-reperfusion injury of the lung, Am. J. Physiol., 268 (Lung Cell. Mol. Physiol.):L1036-L1046 (1995).
Neely et al.; A.sub.1 -adenosine receptor antagonists block endotoxin-induced lung injury, Am. J. Physiol., 272 (Lung Cell Mol. Physiol. 16):L353-L361 (199&).
Neely et al.; A.sub.1 Adenosine Receptor Antagonists Block Ischemia-Reperfusion Injury of the Heart; Circulation 94: (Suppl II): II-376-II-380 (1996).
Salmon et al.; Human Mononuclear Phagocytes Express Adenosine A.sub.1 Receptors, J. Immunology, 151:2775-2785 (1993).
Thornton et al.; Both in vitro and in vivo irradiation are associated with induction of macrophage-derived fibroblast growth factors, Clin. Exp. Immunol. 103:67-73 (1996).
Azpuru Carlos
Link Technology Inc.
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