Methods for the preparation of salts of...

Details Methods for the preparation of salts of... Methods for the preparation of salts of...

2006-08-31

2011-10-11

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S551000

Reexamination Certificate

active

08034805

ABSTRACT:
A method for the preparation of salts of 2-[2-(4-dibenzo[b,fj[1,4]thiazepin-11-yl-1 -piperazinyl)ethoxy]ethanol (quetiapine) from the quetiapine base and the respective acid, wherein the salt is precipitated from a mixture of solvents, the mixture being either a mixture of an aromatic hydrocarbon and a ketone or ester, or that of an aromatic hydrocarbon, water and a ketone or ester. The salts of quetiapine are purified by partial crystallization, wherein only a part of the salt of quetiapine is dissolved in a C1to C6alcohol used.

REFERENCES:
patent: 6372734 (2002-04-01), Snape
patent: 2004/0220400 (2004-11-01), Diller
patent: 2004/0242562 (2004-12-01), Parthasaradhi et al.
patent: 2006/0063927 (2006-03-01), Etlin et al.
patent: 0 240 228 (1987-10-01), None
patent: WO 03/080065 (2003-10-01), None
patent: WO 2004/078735 (2004-09-01), None
patent: WO 2006/027789 (2006-03-01), None
patent: WO 2006/135544 (2006-12-01), None
International Search Report for International Application No. PCT/CZ2006/000054 mailed Jun. 1, 2007.

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