Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2007-05-01
2007-05-01
Habte, Kahsay (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C548S538000, C548S559000
Reexamination Certificate
active
11019788
ABSTRACT:
Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I):or a pharmaceutically acceptable salt or solvate thereof, wherein R1through R6and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
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Doubleday Wendel William
Dyckman Alaric J.
Godfrey, Jr. Jollie Duaine
Grosso John A.
Hynes, Jr. John
Bristol--Myers Squibb Company
Habte Kahsay
Wang Joseph C.
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