Methods for the preparation of pure homologous series of mono to

Details Methods for the preparation of pure homologous series of mono to Methods for the preparation of pure homologous series of mono to

1994-12-16

1997-04-29

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 185, 536 186, 536115, 536123, C07H 1506, C07G 300

Patent

active

056250444

ABSTRACT:
The present invention relates to a method for the making pure homologous series of fatty acyl esters of sugars. The production mono- to tetrapalmitates of maltose is particularly examplified. Specific compositions containing di-, tri- and tetrapalmitates of maltose show an antitumoral activity, an immunostimulating and, to some extent, an antiangiogenic effects are also described and claimed. They can be used alone or in the presence of angiostatic steroids for treating angiogenesis-dependent deseases. The characterization of one such new compound, maltose 1, 6, 6' tripalmitate which is the active component of this series is included.

REFERENCES:
Abstract, JP 61-068497, issued Apr. 8, 1986, to Wakabayashi Toshio et al., entitled "Sugaralcohol Ester Derivative and Neutrophils Activator Containing Same", from Patent Abstracts of Japan.
O. Benrezzak et al., "Modulation of Protein Kinase C Activity by Palmitoyl Esters of Maltose", Cancer Biochem. Biophys., 13, 13-22 (1992).
O. Benrezzak et al., "Effect of Maltose Tetrapalmitate on Tumor Vascularization and Tumor Growth", Anticancer Research, 9, 1815-1818 (1989).
O. Benzerrak et al., "Evaluation of Cortisone-Heparin and Cortisone-Maltose Tetrapalmitate Therapies Against Rodent Tumors. I. Biological Studies", Anticancer Research, 2, 1883-1888 (1989).
Benrezzak, O. et al. (1989) Anticancer Research. 9: 1883-1887.
Chen et al. (1973). J. Infect. Dis. 128: S43-S51.
Nishikawa, Y. et al. (1981). Chem. Pharm. Bull. 29 (2): 505-513.
Spiro, R.G. (1966). Methods in Enzymology 8 pp. 3-52.

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