Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Reexamination Certificate
2011-08-23
2011-08-23
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
C435S252300, C435S232000
Reexamination Certificate
active
08003356
ABSTRACT:
Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH.
REFERENCES:
patent: 5484716 (1996-01-01), Katsumata et al.
patent: 6368837 (2002-04-01), Gatenby et al.
patent: 6521748 (2003-02-01), Tang
patent: 7378261 (2008-05-01), Ben-Bassat et al.
patent: 2003/0079255 (2003-04-01), Qi et al.
patent: 2004/0059103 (2004-03-01), Huang et al.
patent: 2004/0229326 (2004-11-01), Ben-Bassat et al.
patent: 2004/0248267 (2004-12-01), Ben-Bassat et al.
Kim et al. phytochem., 1996, vol. 43 pp. 351-357.
Kyndt et al. FEBS lett 2002, 512, 240-244.
Stancik et al. J. Bactrol. 2002, 184, 4246-4258.
Wookey et al. J. bactrol. 1984, 166, 169-174.
Crocker et al. Microbiol. 2000, 146, 1295-1310.
Hitchcock , J. Gen. physiol. 1924, 747-757.
U.S. Appl. No. 10/138,970, filed May 3, 2002, Qi et al.
U.S. Appl. No. 10/824,237, filed Apr. 14, 2004, Ben-Bassat et al.
Daniel S. Hodgins, Purification, Properties, and the Identification of Catalytically Essential Dehydroalanine, The Journal of Biological Chemistry, vol. 246(9):2977-2985, 1971.
Christopher T. Evans et al., Biotransformation of trans-cinnamic acid to L-phenlalanine: optimization of reaction conditions using whole yeast cells, Enzyme Microb. Technol., vol. 9:417-421, 1987.
Christopher T. Evans et al., Novel stabilization of phenlalanine ammonia-lyase catalyst during bioconversion of trans-cinnamic acid to L-phenylalanine, Appl. Microbiol., Biotechnol., vol. 25:399-405, 1987.
Christopher T. Evans et al, Effect of glycerol, polyethylene glycol and glutaraldehyde on stability of phenylalanine ammonia-lyase activity in yeast, Journal of Industrial Microbiology, vol. 2:53-58, 1987.
Jens Rosler et al., Maize Phenylalanine Ammonia-Lyase Has Tyrosine Ammonia-Lyase Activity, Plant Phys., vol. 113:175-179, 1997.
S. Funfgelder et al., The Activity of Phenylatanine Ammonia-Lyase in Apple Leaves After Wounding, Acta Horticulture, vol. 381:474-478, 1994.
Hye-Won Lim et al., Purification and Properties of Phenylalanine Ammonia-Lyase from Leaf Mustard, Mol. Cells., vol. 7(6):715-720, 1997.
Hye-Won Lim et al., Purification and Properties of Phenylalanine Ammonia-Lyase from Chinese Cabbage, Journal of Biochemistry and Molecular Biology, vol. 31(1):31-36, 1998.
Hye-Won Lim et al., A Second Form of Phenylalanine Ammonia-Lyase from Leaf Mustard, Mol. Cells, vol. 8(3):343-349, 1998.
Annamraju D. Sarma et al., Purification and characterization of UV-B Induced phenylalaine ammonia-lyase from rice seedings, Phytochemistry, vol. 50:729-737, 1999.
A.A. Ameapuymrh et al.. Biotekhnologiya, vol. 2:24-28, 2000.
Jesus Jorrin et al., Purification and properties of phenylalanine ammonia-lyase from sunflower (Helianthus annusL.) hypocotyls, Biochimica et Biophysica Acta, vol. 964:73-82, 1988.
Cochrane, Fiona C. et al., TheArabidopsisphenylalanine ammonia lyase gene family: kinetic characterization of the four PAL isoforms, Phytochemistry, Jun. 20, 2004, 1557-1564. vol. 65, Elsevier Ltd.
Kim, Seong Hwan et al., Purification and Charcterization of Phenylalanine Ammonia-Lyase From Ustilago Maydis, Phytochemistry, Mar. 18, 1996, 351-357, vol. 43, No. 2, Elsevier Science Ltd., Great Britain.
Gale, E.F. and Epps, H.M.R., The effect of the pH of the medium during growth on the enzymatic activities of bacteria (Escherichia coliandMicrococcuslysodeikticus) and the biological significances of the changes produced, Biochemical J. (1942) 36(7-9):600-618.
Zilberstein, D. et al., “Escherichia coliintracellular pH, membrane potential, and cell growth,” J. Bacteriol. (1984) 158 (1):246-252.
Ben-Bassat Arie
Huang Lisa L.
Lowe David J.
Patnaik Ranjan
Sariaslani Fateme Sima
E. I. Du Pont de Nemours and Company
Meah Younus
Saidha Tekchand
LandOfFree
Methods for the preparation of para-hydroxycinnamic acid and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for the preparation of para-hydroxycinnamic acid and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the preparation of para-hydroxycinnamic acid and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2783139