Methods for the preparation of novel sidechain-bearing taxanes

Details Methods for the preparation of novel sidechain-bearing taxanes Methods for the preparation of novel sidechain-bearing taxanes

1996-02-13

1999-10-26

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548237, 549220, 549510, 549511, 549473, 549214, C07D30514

Patent

active

059731605

ABSTRACT:
Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.

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