Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Reexamination Certificate
2009-07-31
2011-11-01
Desai, Anand (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
C435S113000, C435S114000, C435S116000, C435S069100, C435S196000, C435S252320, C435S471000, C536S023200
Reexamination Certificate
active
08048651
ABSTRACT:
The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g.,Corynebacteriumby way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine inCorynebacterium glutamicumby way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
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Haefner Stefan
Heinzle Elmar
Kiefer Patrick
Klopprogge Corinna
Kröger Burkhard
BASF SE
Chowdhury Iqbal H
Connolly Bove & Lodge & Hutz LLP
Desai Anand
LandOfFree
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