Methods for the preparation of immunogens against gastrin

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

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42419711, 530300, 530326, 530327, 530328, 530329, 530330, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, C07K 500, A61K 3900, A61K 39385, A61K 3800

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active

056098707

ABSTRACT:
Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.

REFERENCES:
patent: 3931141 (1976-01-01), Wissman et al.
patent: 4384995 (1983-05-01), Stevens
patent: 4565805 (1986-01-01), Smirnov et al.
patent: 4687759 (1987-08-01), Martinez et al.
patent: 4691006 (1987-09-01), Stevens
patent: 5023077 (1991-06-01), Gevas et al.
Sugano et al., The Journal of Biological Chemistry, vol. 260, No. 21, Sep. 25, 1985, pp. 11724-11729.
Jaffe et al., Gastroenterology, vol. 58, No. 2, Feb. 1970, pp. 151-156.
Jaffe et al., Surgery, vol. 69, No. 2, Feb. 1971, pp. 232-237.
Jaffe et al., Surgery, vol. 65, No. 4, Apr. 1969, pp. 633-639.
Hughes et al., Digestive Diseases, vol. 21, No. 3, Mar. 1976, pp. 201-204.
Wunsch et al., Z. Physiol. Chem. Jun. 1982, pp. 666-669.
Iwanaga, et al., Biomed. Res. 1: 316-320, 1980.
Larsson, Neurohistochemoistry: Modern Methods and Applications, 1986, pp. 527-567.
Moroder et al., Gastrin and Cholecystokinin, Chemistry, Physiology and Pharmacology, 1987, pp. 21-32.
Dockray et al., Gastroenterology, vol. 68, No. 2, Feb. 1975, pp. 222-230.
Choudhury et al., Z. Physiol. Chem., Nov. 1980, pp. 1719-1733.
Azuma et al. Gastroenterologia Japonica, vol. 21, No. 4, Aug. 1986, pp. 319-324.
Varndell et al., Experientia, 39, 1983, pp. 713-717.
Larsson et al., J. Histochem. Cytochem. 25: 1317-1321, 1977.
Rehfeld et al. Scand. J. Clin. Lab. Invest., 30, 1972, pp. 221-232.
De Magistris et al., Analytical Biochemistry, 102, 1980, pp. 126-133.
Rehfeld et al., Regulatory Peptides, 2, 1981, pp. 333-342.
Yamaguchi, K., et al., Chem. Abs., 100: 154661m, pp. 373, (1983).
Dockray, "Regulatory Peptides", 1, 169-186 (1980).
Yanaihara, et al., "Biomedical Research", 1, 242-247 (1980).
Nemeth, et al., Chem. Abs. 98: 51653W, p. 495, 1982.
Nemeth, et a., Izotoptechnika 25: 288-294, 1982.
Yanaihara et al., "Gut Peptides", 26-33 (1979).
Beauchamp et al., Ann.Surg., 202, Sep. 1985, pp. 303-309.
Kothary, et al., Biochen. Biophys. Res. Comm. 146: 884-888, 1987.
Lamote et al., Regulatory Peptides, 20, 1988, pp. 1-9.
Lamers et al., Eur. J. Cancer Clin. Oncol., vol. 24., No. 2, 1988, pp. 267-273.
Watson et al., in vitro, Br. J. Surg., vol. 75, Apr. 1988, pp. 342-345.
Kusyk et al., Am. J. Physiol., 251, 1986, pp. G597-G601.
Weinstock et al., Cancer Research, 48, Feb. 15, 1988, pp. 932-937.
Upp et al., Cancer Research, 49, Jan. 15, 1989.
Upp et al. Ann. Surg. vol. 207, No. 6, Jun. 1988 pp. 662-669.
Smith et al., Digestive Diseases and Science, vol. 34, No. 2, Feb. 1989, pp. 171-174.
Dockray, Chem. Abst. 94, 119200W, p. 506 (1980).
Smith et al., Gastroenterology, 95 1988, pp. 1541-1548.
Upp et al. Ann. Surg. vol. 207, No. 6, Jun. 1988 pp. 662-669.
Rae-Venter, et al., Gastroenterology, 80: p. 1256, 1986.
Azuma et al. 1986. Immunocytochemical evidence for differential distribution . . . Gastroenterologia Japonica 21(4):319-24.
Gregory et al. 1966. Isolation of Two Gastrins from Human Antral Mucosa. Nature 209(5023):583.
Bentley et al. 1966. Structures of Human Gastrins 1 & 11 Nature. 209(5023):583-85.
Beacham et al. 1966. Synthesis of Human Gastrin 1. Nature 209(5023):585-86.
Seimann 1987. "Satisfactory and Unsatisfactory Tumor Models . . . " in Rodent Tumor Models in Experimental Cancer Therapy. ed. Kallman. pp. 12-15. Pergamon Press., New York.

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