Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles
Reexamination Certificate
2008-06-10
2008-06-10
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitriles
C564S167000
Reexamination Certificate
active
07385072
ABSTRACT:
The invention disclosed in this application relates to an improved process for the preparation of Entacapone. In one embodiment the process involves: (i) reacting a 3-alkoxy-4-hydroxy-5-nitrobenzadehyde with N,N-diethylaminocyanoacetamide in the presence of a mild acid catalyst and a solvent, to provide a 3-O-alkylated Entacapone, and treating the 3-O-alkylated Entacapone with an acid catalyst in the presence of an organic base to provide Entacapone.
REFERENCES:
patent: 4963590 (1990-10-01), Backstrom et al.
Wikeberg et al, Drug metabolism and Disposition, vol. 21, No. 1, pp. 81-92, 1993.
Md Samjuddin Md
Rajendiran Chinnapillai
Reddy Arava Veera
Venkateswarlu Jasti
Kumar Shailendra
Schwegman Lundberg & Woessner, P.A.
Suven Life Sciences
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