Methods for the preparation of controlled gastric residence time

Details Methods for the preparation of controlled gastric residence time Methods for the preparation of controlled gastric residence time

1976-11-23

1978-05-09

Smith, Ronald H.

Coating processes

Fraud or tamper detecting

424 33, 424 19, A61K 900

Patent

active

040887987

ABSTRACT:
Controlled gastric residence time medicament formulations, e.g., tablets and/or capsules, containing polymeric film coatings are exposed to a volatile amine, e.g., anhydrous ammonia, methyl amine, or ethyl amine, to provide improved medicament formulations, which by virtue of mechanical or surface effects including expansion or swelling of the coating in gastric fluids are capable of prolonged, e.g., up to twelve hours, residence in the gastric area.

REFERENCES:
patent: 3143472 (1964-08-01), Lappas
patent: 3407157 (1968-10-01), Carstensen
patent: 3442698 (1969-05-01), Dill
patent: 3878151 (1975-03-01), Dach
patent: 3959540 (1976-05-01), Leiberich

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