Methods for the preparation of...

Details Methods for the preparation of... Methods for the preparation of...

2008-04-25

2011-12-13

Sullivan, Daniel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C549S464000

Reexamination Certificate

active

08076513

ABSTRACT:
A process for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives in which a (1-benzyl-2-hydroxy-3-isobutylamino-propyl)-carbamic acid derivative is reacted with a p-nitrophenylsulfonyl halide to provide the desired product in a high yield and degree of purity.

REFERENCES:
patent: 6867321 (2005-03-01), Ikemoto et al.
patent: 2004/0162340 (2004-08-01), Ikemoto et al.
patent: 0715618 (1998-12-01), None
patent: 0754669 (2001-10-01), None
patent: 0810209 (2002-06-01), None
patent: 0885887 (2003-05-01), None
patent: 1081133 (2004-03-01), None
patent: 1029856 (2004-06-01), None
patent: 1215209 (2004-08-01), None
patent: 1067125 (2006-07-01), None
patent: WO 95/06030 (1995-03-01), None
patent: WO 97/18205 (1997-05-01), None
patent: WO 99/65870 (1999-12-01), None
patent: WO 99/67254 (1999-12-01), None
patent: WO 99/67417 (1999-12-01), None
patent: WO 00/47551 (2000-08-01), None
patent: WO 00/76961 (2000-12-01), None
patent: WO 01/46120 (2001-06-01), None
patent: WO 03/022853 (2003-03-01), None
patent: WO 2004/033462 (2004-04-01), None
patent: WO 2005/063770 (2005-07-01), None
patent: WO 2005/095410 (2005-10-01), None
Flosi, W., et al. “Discovery of Imidazolidine-2,4-Dione-Linked HIV Protease Inhibitors With Activity Against Lopinavir-Resistant Mutant HIV”, Bioorganic & Medical Chemistry 14 (2006) pp. 6695-6712.
Ghosh, A., et al. Steroselective Photochemical 1,3-Dioxolane Addition to 5-Alkoxyrnethyl-2(5H)-Furanone: Synthesis of Bis-Tetrahydrofuranyl Ligand for HIV Protease Inhibitor UIC-94017 9TMC-114), JOC 2004, v69, p. 7822.
March, Jerry, “Advanced Organic Chemistry”, (3rdEd. 1985), pp. 368-369.
McManus, Samuel, et al., “The Synthesis of Aminoalcohols From Epoxides and Ammonia”, Synthetic Communications, (1973), pp. 177-180, vol.-issue 3(3).
International Search Report (date of mailing Aug. 22, 2008) for corresponding Patent Application No. PCT/EP2008/055042.

Affiliated with

Also associated with

Rating

Methods for the preparation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the preparation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the preparation of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4314711