Methods for the isolation of heparin-binding brain mitogens

Details Methods for the isolation of heparin-binding brain mitogens Methods for the isolation of heparin-binding brain mitogens

1992-09-14

1993-12-14

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530399, 530413, 530415, 530416, 530427, C07K 1508, C07K 318, C07K 322, C07K 328

Patent

active

052704491

ABSTRACT:
A group of growth factors, designated heparin-binding brain mitogens (HBBMs), is disclosed. The HBBMs are isolated from brain tissue by a sequence of purification steps. The growth factors may be useful in the promotion of angiogenesis, such as in the promotion of wound healing, bone healing and in the treatment of burns, as well as in promoting the formation, maintenance and repair of tissue, in particular, neural tissue.

REFERENCES:
Bohlen et al. 1984. Proc. Natl. Acad. Sci. 81:5364-5368.
Smith et al. 1984. Biochem Biophys. Res. Comm. 119(1):311-318.
Kato, Y. 1987. Adv. Chromatogr. 26:97-115.
Milner et al. 1989. Biochem. Biophys. Res. Comm. 165(3):1096-1103.
Merenmier et al. 1990. J. Biol. Chem. 265(28):16721-16724.
Tezuka et al. 1990. Biochem Biophys. Res. Comm. 173(1):246-251.

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