Chemistry: analytical and immunological testing – Including sample preparation – Liberation or purification of sample or separation of...
Reexamination Certificate
2005-11-29
2005-11-29
Minnifield, N. M. (Department: 1645)
Chemistry: analytical and immunological testing
Including sample preparation
Liberation or purification of sample or separation of...
C436S164000, C436S178000, C435S006120, C435S004000, C435S007100, C435S007900, C435S040500, C435S040520
Reexamination Certificate
active
06969614
ABSTRACT:
The present invention describes devices and methods for performing protein analysis on laser capture microdissected cells, which permits proteomic analysis on cells of different populations. Particular disclosed examples are analysis of normal versus malignant cells, or a comparison of differential protein expression in cells that are progressing from normal to malignant. The protein content of the microdissected cells may be analyzed using techniques such as immunoassays, 1D and 2D gel electrophoresis characterization, Western blotting, liquid chromatography quadrapole ion trap electrospray (LCQ-MS), Matrix Assisted Laser Desorption Ionization/Time of Flight (MALDI/TOF), and Surface Enhanced Laser Desorption Ionization Spectroscopy (SELDI). In addition to permitting direct comparison of qualitative and quantitative protein content of tumor cells and normal cells from the same tissue sample, the methods also allow for investigation of protein characteristics of tumor cells, such as binding ability and amino acid sequence, and differential expression of proteins in particular cell populations in response to drug treatment. The present methods also provide, through the use of protein fingerprinting, a rapid and reliable way to identify the source tissue of a tumor metastasis.
REFERENCES:
patent: 4976957 (1990-12-01), Bogoch
patent: 5843644 (1998-12-01), Liotta et al.
patent: 5843657 (1998-12-01), Liotta et al.
patent: 6010888 (2000-01-01), Liotta et al.
patent: 6251467 (2001-06-01), Liotta et al.
patent: 6251516 (2001-06-01), Bonner et al.
patent: 6569639 (2003-05-01), Liotta et al.
patent: 6602661 (2003-08-01), Knezevic et al.
patent: 6680203 (2004-01-01), Dasseux et al.
patent: 6699721 (2004-03-01), Peterson et al.
patent: 6790636 (2004-09-01), Star et al.
patent: 61 275221 (1986-12-01), None
patent: WO 99/44062 (1999-09-01), None
patent: WO 99/44063 (1999-09-01), None
Suarez-Quian et al, Bio Techniques, Feb. 1999, 26:328-335.
Olsen et al, Neuroendocrinology, 1989, 50/4:392-399 Abstract only.
Dolter et al, BioTechniques, Jun. 2001, 30/6:1358-1361 Abstract only.
Lindeman et al, Diagn. Mol. Pathol., Dec. 2002, 11/4:187-192 Abstract only.
Kobayashi et al., J. Vet. Med. Sci., 2003, 65/8:917-919.
Ornetein et al, Clinical Cancer Research, Feb. 2000, 6:353-356.
Evans et al, Reprod. Biol. Endocrinol. 2003, 1/1:54.
Trogan et al, PNAS USA, Feb. 2002, 99/4:2243-2239.
Sluka et al, Biology of Reproduction, 2002, 67:820-828.
Nakazono et al, The Plant Cell, Mar. 2003, 15/3:583-596.
Heinmoller et al, Pathol. Res. Pract., 2003, 199/6:363-371 Abstract only.
Tsukamoto et al, Cancer Sci., Dec. 2003, 94/12:1046-1051.
Casanova et al, BioTechniques, Feb. 2002, 32/2:242-248.
Burbach et al, J. Neuroscience Methods, 2004, 138:141-148.
Luo et al, Nature Medicine, Jan. 1999, 5/1:117-122.
Bartorfi et al, Gynecological Oncology, 2003, 88:424-428.
Sacci et al, Molecular and Biochemical Parasitology,2002, 119:285-289.
Zhan et al, Neuroscience, 2002, 113/1:145-154.
Paradis et al, Methods in Enzymology, 2002, 356:129-136.
Jain, Methods in Enzymology, 2002, 356:157-167.
Reilly et al, Brain Research Reviews, 2004, 46:225-233.
Banks et al, Electrophoresis, 1999, 20/4-5:689-700.
Emmert-Buck et al, Science, 1996, 274/5289:998-1001.
Ornstein et al, Electrophoresis, 2000, 21:2235-2242.
Banks et al., “The potential use of laser capture microidissection to selectively obtain distinct population of cells for proteomic analysis—Preliminary findings,”Electrophoresis20:689-700, Apr. 1999.
Cazares et al., “Discovery of prostate cancer biomarkers from laser capture microdissected (LCM) cells using innovative ProteinChipTM SELDI mass spectroscopy,”Proceedings of the American Association for Cancer Research Annual Meeting(91stAnnual Meeting, San Francisco, CA, USA) p. 851 (abstract), Mar. 2000.
Emmert-Buck et al., “An approach to proteomic analysis of human tumors,”Molecular Carcinogenesis27:158-165, Mar. 2000.
Emmert-Buck et al., “Protein fingerprinting of LCM-dissected human esophageal and prostate cancer by 2D-PAGE,”Proceedings of the American Association for Cancer Research Annual Meeting(90thAnnual Meeting, Philadelphia, PA, USA) 40(526):526 (abstract), Mar. 1999.
Simone et al., “Laser-capture micro-dissection: opening the microscopic frontier to molecular analysis,”Trends in Genetics14(7):272-276, Jul. 1, 1998.
Simone et al., “PSA quantitation in prostate cancer tissue cells procured by laser capture microdissection,”Proceedings of the American Association for Cancer Research Annual Meeting(90thAnnual Meeting, Philadelphia, PA, USA) 40:411 (abstract), Mar. 1999.
Emmert-Buck et al.,Am. J. Pathol., 145(6):1285-1290, 1994.
Klimek et al.,Carcingenesis, 11(8):1377-1380, 1990.
Im et al.,J. Craniofacial Genetics&Dev. Biol., 3:281-288, 1983.
Moore et al.,J. Cell Biol., 105:1377-1386, 1987.
Pappalardo et al.,Seminars in Radiation Oncol., 8(3):217-223, 1998.
Emmert-Buck Michael
Liotta Lance A.
Petricoin III Emmanuel F.
Simone Nicole
Minnifield N. M.
The United States of America as represented by the Department of
LandOfFree
Methods for the isolation and analysis of cellular protein... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for the isolation and analysis of cellular protein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the isolation and analysis of cellular protein... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3487230