Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2006-05-23
2006-05-23
Qian, Celian (Department: 1633)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C623S001420, C514S291000
Reexamination Certificate
active
07048939
ABSTRACT:
Restenosis is inhibited through local delivery of anti-restenotic agents including angiotensin converting enzyme inhibitors; nicotine receptor agonists, agents that increase concentrations of nitric oxide, anti-angiogenic agents, agonists of the TGF-beta receptor; death domain receptor ligands; and thrombin inhibitors. In one embodiment of the invention, the localized delivery is effected through the use of a stent modified for delivery of the agent at the site of injury from balloon angioplasty.
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Ettenson, D. et al., Local Drug Delivery: An Emerging Approach in the Treatment of Restenosis, Vascular Medicine, (2000), vol. 5: 97-102.
Gunn, J. et al., Stent Coatings and Local Drug Delivery State of the Art, European Heart Journal, (1999), vol. 20: 1693-1700.
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Dake Michael D.
Elkins Christopher J.
Waugh Jacob M.
Bozicevic Field & Francis LLP
Nquyen Quang
Qian Celian
Sherwood Pamela J.
The Board of Trustees of the Leland Stanford Junior University
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