Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1993-04-23
1995-11-21
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 1286534, 128654, 514492, 514502, 514836, 424 9363, 424 9364, A61B 5055
Patent
active
054684676
ABSTRACT:
Methods wherein the concentration of NMR-detectable xenobiotic compounds may be determined in living subjects by in vivo measurement of one or more magnetic resonance signals. In preferred embodiments, the present invention provides a method for evaluating, in vivo, the clearance rate of a xenobiotic compound from a living subject, thereby providing a noninvasive method for determining the status of the excretory organs of the subject, and a method for determining the proper dosing regimen of a pharmacologically active compound to be administered to the subject.
REFERENCES:
patent: 3932805 (1976-01-01), Abe et al.
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 4984573 (1991-01-01), Leunbach
patent: 5100646 (1992-03-01), Choyke et al.
patent: 5190744 (1993-03-01), Rocklage et al.
patent: 5234680 (1993-08-01), Rogers, Jr. et al.
patent: 5248498 (1993-09-01), Neomann et al.
patent: 5250284 (1993-10-01), Krongrad
Smith, W. B., "Nuclear Magnetic Resonance"; Enccyclopedia of Chemistry, pp. 732-736 (1973).
Battocletti, "Blood Flow Measurement by NMR"; CRC Critical Reviews in Biomedical Engineering, CRC Press Inc., vol. 13, Is. 4, pp. 311-367 (1986).
Salles-Cunha et al., "The NMR Blood Flowmeter-Applications"; Med. Phys. 8(4), pp. 452-458 Jul./Aug. (1981).
Battocletti et al., "The NMR Blood Flowmeter-Theory and History"; Med. Phys. 8(4), pp. 435-443, Jul./Aug. (1981).
Halbach et al., "The NMR Blood Flowmeter-Design"; Med. Phys, 8(4), pp. 444-451 Jul./Aug. (1981).
Malfertheiner et al., "NMR (Nuclear Magnetic Resonance)-A Non Intrusive Technique for Measurement of Blood Flow", vol. 6, No. 3, pp. 186-194, Sep. (1976).
Halbach et al., "Blood Flow Imaging Techniques Using of NMR"; IEEE 1982 Frontiers of Engineering in Health Care, pp. 557-560, Phila., PA, Sep. 20-21 (1982).
Tweedle, M. F., Work in Progress Toward Nonionic Macrocyhclic Gadolinium (III) Complexes; Contrast and Contrast Agents in Magnetic Resonance Imaging (Ed. Peter A. Rinck), pp. 65-73 (1988).
Ohgushi et al., "Dextran-Magnetite: A New Relaxation Reagent and Its Application to T.sub.2 Measurements in Gel Systems", Journal of Magnetic Resonance, 29, pp. 599-601 (1978).
Choyke et al., "Hydrated Clearance of Gadolinium-DTPA as a Measurement of Glomerular Filtration Rate"; Kidney International, vol. 41, pp. 1595-1598 (1992).
Berthezene et al., Safety Aspects and Pharmacokinetics of Inhaled Aerosolized Gadolinium; Journal Magnetic Resonance Imaging, vol. 3, No. 1, pp. 125-130 (1993).
Tweedle, "Relaxation Agents in NMR Imaging"; J-C G. Bunzli and G. R. Choppin, Lanthanide Probes in Life, Chemical, and Earth Sciences, Chapter 5, pp. 127-179 (Elsevier, 1989).
Rubenstein, E., "Magnetic Resonance Imaging, Imaging with Photons"; Current Topics in Medicine (1988).
Armstrong et al., "Magnetic Resonance Imaging-Basic Principles of Image Production"; British Medical Journal, vol. 303, p. 35 (1991).
Armstrong et al., "Magnetic Resonance Imaging-Clinical Uses"; British Medical Journal, vol. 303, p. 105 (1991).
Shulman et al., "Nuclear Magnetic Resonance Spectroscopy in Diagnostic and Investigative Medicine", J. Clin. Invest., vol. 74, pp. 1127-1131 (1984).
Tweedle, M. F., "Gadolinium Chelates as Relaxation Agents in Magnetic Resonance Imaging", Journal of Alloys and Compounds, 180, pp. 317-323 (1992).
Tweedle, M. F., "Nonionic or Neutral?"; Radiology, vol. 178, No. 3, 891 (1991).
Ross et al., "Examination of a Case of Suspected McArdle's Syndrome By .sup.31 P Nuclear Magnetic Resonance"; The New England Journal of Medicine, vol. 304, No. 22, pp. 1338-1342 (1981).
S-E Back et al., "Contrast Media and Glomerular Filtration: Dose Dependence of Clearance for Three Agents", J. Pharm. Sci, 77, 765 (1988).
Scan Magazine, "Esaote builds unit to catch Niche MRI trend" (2 pages) and Metriflow pioneers trend to market niche MR (1 page) (1992).
Gaughan, G., "Nonionic Gadolinium Chelates"; Enhanced Magnetic Resonance Imaging, Contrast Media Principles, pp. 105-116, C. B. Mosby Co., edited by Val M. Rounge (1989).
Nunn Adrian D.
Strauss Harry W.
Tweedle Michael F.
Bracco International B.V.
Hollinden Gary E.
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