Methods for the identification of inhibitors which suppress the

Details Methods for the identification of inhibitors which suppress the Methods for the identification of inhibitors which suppress the

1995-08-25

1999-11-30

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

530350, G01N 3353

Patent

active

059940824

ABSTRACT:
The invention relates to inhibitors suppressing the activity of transacting proteins which are essential for the general control of vertebrate MHC class II gene expression and methods for identifying the same. The invention additionally relates to pharmaceutical compositions containing said inhibitors, preferably for the treatment of diseases which are associated with an aberrant expression of MHC class II genes.

REFERENCES:
patent: 5672473 (1997-09-01), Glimcher et al.
Mach, B. et al., MHC Class II-Deficient Combined Immunodeficiency: a Disease of Gene Regulation, Immunol. Rev ., 138, pp. 207-221 (1994).
Mach, B. et al., MHC Class I and Class II, Res. Immunol ., 144, pp. 525-526 (1993).
Reith, W. et al., Cloning of RF--X, the MHC Class II Promoter Binding Protein Affected in a Hereditary Defect in Class II Gene Regulation, Experientia, 45, pp. a22 abstract 73 (1989).
Steimle, V. et al., Cloning of an HLA Class II Transactivator Defective in a Form of Primary Immunodeficiency by Genetic Complementation, Experientia, pp. a7 abstract 41 (1993).
Glimcher, et al. 1992. Ann. Rev. Immunol. vol. 10, pp. 13-49. "Sequences and Factors: A guide to MHC Class II Transcription".
Steimle, et al. 1993. Cell. vol. 75 pp. 135-146. "Complementation Cloning of an MHC Class II Transactivator Mutated in Hereditiry . . .".

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