Methods for the identification of compounds useful for the...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007200, C554S117000

Reexamination Certificate

active

06878522

ABSTRACT:
The present invention relates to the discovery that PDG2is the nautral ligand for orphan receptor CRTH2, which interaction, it will now immediately be recognized, is important in the development of valuable pharmaceuticals. The present invention is therefore related to methods for screening for therapeutic compounds useful in the treatment of PGD2-related disorders such as allergy, asthma and inflammation. Appropriate assay methodology is also disclosed.

REFERENCES:
patent: 3885041 (1975-05-01), Aspinall et al.
patent: 0253094 (1988-01-01), None
patent: 0322153 (1989-06-01), None
patent: WO 0114882 (2000-08-01), None
H. Tsuda, et al., Clin Exp Immunol, vol. 123, pp. 105-111, (2001).
H. Hirai, et al., J. Exp. Med., vol. 193, pp. 255-261, (2001).
Lorenzo Cosmi, et al., Eur. J. Immunol., vol. 30, pp. 2972-2979, (2000).
Kinya Nagata, et al., FEBS Letters, vol. 459, pp. 195-199, (1999).
Hiroyuki Abe, et al., Gene, vol. 227, pp. 71-77, (1999).
Kinya Nagata, et al., The Journal of Immunology, vol. 162, pp. 1278-1286 (1999).
Leitinger, et al., Thrombosis Research, vol. 86, No. 4, pp337-342, 1997.
Bundy, et al., J. Med. Chem. 1983, 26, pp. 790-799.
Flower, et al., Br. J. Pharmac, 1976, 56, pp. 229-233.
Monneret, et al., Jrnl of Pharm. And Experimental Therapeutics, vol. 504, No. 1, pp. 349-355, 2003.
Menciu et al., Jrnl of Medicinal Chem., 1999, vol. 42, No. 4, 638-648.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for the identification of compounds useful for the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the identification of compounds useful for the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the identification of compounds useful for the... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3407580

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.