Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-15
2006-08-15
Turner, Sharon (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S007100
Reexamination Certificate
active
07090987
ABSTRACT:
The invention features methods of diagnosing and treating a patient having Alzheimer's disease or other neuronal atrophy-associated dementia by determining or altering, respectively, the level of activity of pathways from the endoplasmic reticulum to lysosomes in the patient.
REFERENCES:
patent: 5028622 (1991-07-01), Plaitakis et al.
patent: 5538983 (1996-07-01), Buxbaum et al.
patent: 5686269 (1997-11-01), Nixon et al.
patent: 0652 012 (1995-05-01), None
patent: WO 97/44668 (1997-11-01), None
patent: WO 98/21589 (1998-05-01), None
patent: WO 98/40484 (1998-09-01), None
Zhao et al., J. of Neuroscience Res., Feb. 1, 1995, 40(2):261.
ATCC web catalog ATCC No. CRL-1721, Rattus norvegticuss PC-12.
Frautschy et al., J. Neurosci., Oct. 15, 1998, 18(20):8311-21.
Tsuzuki et al., Brain Research, 1994, 659:213-220.
Bjarnadottir et al., “Intracellular Accumulation of the Amyloidogenic L68Q Variant of Human Cystatin C in NIH/3T3 Cells,” Journal of Clinical Pathology: Molecular Pathology 51:317-326 (1998).
Busca et al. “The Carboxy-Terminal Region of Human Lipoprotein Lipase is Necessary for its Exit From the Endoplasmic Reticulum,” Journal of Lipid Research 39:821-833 (1998).
Cataldo et al., “Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer's Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis,” Journal of Neuroscience 17:6142-6151 (1997).
Cataldo et al., “Lysosomal Hydrolases of Different Classes are Abnormally Distributed in Brains of Patients with Alzheimer Disease,” Proceedings of the National Academy of Sciences (USA) 88:10998-11002 (1991).
Cataldo et al., “Lysosomal Abnormalities in Degenerating Neurons Link Neuronal Compromise to Senile Plaque Development in Alzheimer Disease,” Brain Research 640: 68-80 (1994).
Cataldo et al., “Properties of the Endosomal-Lysosomal System in the Human Central Nervous System: Disturbances Mark Most Neurons in Populations at Risk to Degenerate in Alzheimer's Disease,” Journal of Neuroscience 16:186-199 (1996).
Dash et al., “Inhibitors of Endocytosis, Endosome Fusion, and Lysosomal Processing Inhibit the Intracellular Proteolysis of the Amyloid Precursor Protein,” Neuroscience Letters 164:183-186 (1993).
Granholm et al., “Segmental Trisomy Ts65Dn Mice Have a Decrease in Nerve Growth Factor Receptors in Septal Forebrain Neurons,” Abstracts, Society for Neuroscience 24:2008, Abstract 803.4 (1998).
Haass et al., “Targeting of Cell-Surface β-Amyloid Precursor Protein to Lysosomes: Alternative Processing into Amyloid-Bearing Fragments,” Nature 357:500-503 (1992).
Holtzman et al., “Developmental Abnormalities and Age-Related Neurodegeneration in a Mouse Model of Down Syndrome,” Proceedings of the National Academy of Sciences (USA) 93:13333-13338 (1996).
Ikegami et al., “Immunohistochemical Examination of Phosphorylated Tau in Granulovacuolar Degeneration Granules,” Psychiatry and Clinical Neurosciences 50: 137-140 (1996).
Korenberg, “Mental Modelling,” Nature Genetics 11:109-111 (1995).
Punnonen et al., “Effects of Vinblastine, Leucine, and Histide, and 3-Methyladenine on Autophagy in Ehrlich Ascites Cells,” Experimental & Molecular Pathology 52:87-97 (1990).
Reeves et al., “A Mouse Model for Down Syndrome Exhibits Learning and Behaviour Deficits,” Nature Genetics 11:177-183 (1995).
Watari et al., “Niemann-Pick C1 Protein: Obligatory Roles for N-Terminal Domains and Lysosomal Targeting in Cholesterol Mobilization,” Proceedings National Academy Sciences 96:805-810 (1999).
Yan Zhou et al., “A Mutation in a Mild Form of Galactosialidosis Impairs Dimerization of the Protective Protein and Renders it Unstable,” EMBO Journal 10:4041-4048 (1991).
U.S. Appl. No. 09/560,124, filed Apr. 28, 2000, Ralph Nixon.
Bucci et al., The Small GTPase rab5 Functions as a Regulatory Factor in the Early Endocytic Pathway, Cell 70:715-28, 1992.
Stenmark et al., Inhibition of rab5 GTPase Activity Stimulates Membrane Fusion in Endocytosis ,EMBO Journal 13:1287-1296, 1994.
Stenmark et al., Rabaptin-5 is a Direct Effector of the Small GTPase Rab5 in Endocytic Membrane fusion, Cell 83:423-32, 1995.
Anglade et al., “Apoptosis and Autophagy in Nigral Neurons of Patients with Parkinson's Disease,” Histol. Histopathol. 12:25-31 (1997).
Bernstein et al., “Lysosomal Proteinases as Putative Diagnostic Tools in Human Neuropathology; Alzheimer Disease (AD) and Schizophrenia,” ACTA Histochem. Suppl. 42:19-24 (1992).
Guo et al., “Alzheimer's Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals,” J. Neurosci. 17:4212-4222 (1997).
Soustek et al., “Autolysosomes in Alzheimer's Disease and Their Possible Role in its Pathogenesis; An Ultrastructural Study,” Zentralbl. Pathol. 140: 143-148 (1994).
Cataldo Anne M.
Mathews Paul M.
Nixon Ralph A.
Bieker-Brady Kristina
Clark & Elbing LLP
Turner Sharon
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