Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2005-01-04
2005-01-04
Falk, Anne-Marie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S008000, C800S009000, C800S012000, C800S018000, C435S325000, C435S455000
Reexamination Certificate
active
06838592
ABSTRACT:
The invention features methods for identifying compounds useful for the treatment of Alzheimer's disease.
REFERENCES:
Mullins et al. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene pp. 541-544 vol. 344 1990.*
Mullins et al. Expression of the DBA/2J ren gene in the adrenal gland of transgenic mice pp. 4065-4072 1989.*
Sigmund Viewpoint: are studies in genetically altered mice out of control pp. 1425-1429 2000.*
Wall Transgenic livestock: progress and prospects for the future pp. 57-68 1996.*
Hammer et al. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human B2m: an animal model of HLA_B27-associated human disorders pp. 1099-1112 1990.*
Taurog et al. HLA-B27 in inbred and non-inbred transgenic mice pp. 4020-4023 No. 11. 1988.*
Bucci et al., The Small GTPase rab5 Functions as a Regulatory Factor in the Early Endocytic Pathway, Cell 70:715-28, 1992.
Stenmark et al. Inhibition of rab5 GTPase Activity Stimulates Membrane Fusion in Endocytosis EMBO Journal 13:1287-1296, 1994.
Stenmark et al Rabaptin-5 is a Direct Effector of the Small GTPase Rab5 in Endocytic Membrane fusion, Cell 83:423-32, 1995.
Bjarnadottir et al., “Intracellular Accumulation of the Amyloidogenic L68Q Variant of Human Cystatin C in NIH/3T3 Cells,” Journal of Clinical Pathology: Molecular Pathology 51:317-326 (1998).
Busca et al., “The Carboxy-Terminal Region of Human Lipoprotein Lipase is Necessary for its Exit From the Endoplasmic Reticulum,” Journal of Lipid Research 39:821-833 (1998).
Cataldo et al., “Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer's Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis,” Journal of Neuroscience 17:6142-6151 (1997).
Cataldo et al., “Lysosomal Hydrolases of Different Classes are Abnormally Distributed in Brains of Patients with Alzehimer Disease,” Proceedings of the National Academy of Sciences (USA) 88:10998-11002 (1991).
Cataldo et al., “Lysosomal Abnormalities in Degenerating Nuerons Link Neuronal Compromise to Senile Plaque Development in Alzheimer Disease,” Brain Research 640: 68-80 (1994).
Cataldo et al., “Properties of the Endosomal-Lysosomal System in the Human Central Nervous System: Disturbances Mark Most Neurons in Populations at Risk to Degenerate in Alzehimer's Disases,” Journal of Neuroscience 16:186-199 (1996).
Dash et al., “Inhibitors of Endocytosis, Endosome Fusion, and Lysosomal Processing Inhibit the Intracellular Proteolysis of the Amyloid Precursor Protein,” Neuroscience Letters 164:183-186 (1993).
Granholm et al., “Segmental Trisomy Ts65Dn Mice Have a Decrease in Nerve Growth Factor Receptors in Septal Forebrain Neurons,” Abstracts, Society for Neuroscience 24:2008, Abstract 803.4 (1998).
Haas et al., “Targeting of Cell-Surface β-Amyloid Precursor Protein to Lysosomes: Alternative Processing into Amyloid-Bearing Fragments,” Nature 357:500-503 (1992).
Holtzman et al., “Development91 Abnormalities and Age-Related Neurodegeneration in a Mouse Model of Down Syndrome,” Proceedings of the National Academy of Sciences (USA) 93:13333-13338 (1996).
Ikegami et al., “Immunohistochemical Examination of Phosphorylated Tau in Granulovacuolar Degeneration Granules,” Psychiatry and Clinical Neurosciences 50: 137-140 (1996).
Korenberg, “Mental Modelling,” Nature Genetics 11:109-111 (1995).
Punnonen et al., “Effects of Vinblastine, Leucine, and Histide, and 3-Methyladenine on Autophagy in Ehrlich Ascites Cells,” Experimental & Molecular Pathology 52:87-97 (1990).
Reeves et al., “A Mouse Model for Down Syndrome Exhibits Learning and Behaviour Deficits,” Nature Genetics 11:177-183 (1995).
Watari et al., “Niemann-Pick C1 Protein: Obligatory Roles for N-Terminal Domains and Lysosomal Targeting in Cholesterol Mobilization,” Proceedings National Academy Sciences 96:805-810 (1999).
Yan Zhou et al., “A Mutation in a Mild Form of Galactosialidosis Imparis Dimerization of the Protective Protein and Renders it Unstable,” EMBO Journal 10:4041-4048 (1991).
Cataldo Anne M.
Mathews Paul M.
Nixon Ralph A.
Bieker-Brady Kristina
Clark & Elbing LLP
Falk Anne-Marie
Nathan S. Kline Institute for Psychiatric Research
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