Methods for the early diagnosis of ovarian cancer

Details Methods for the early diagnosis of ovarian cancer Methods for the early diagnosis of ovarian cancer

2005-03-22

2005-03-22

Ungar, Susan (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S350000, C530S328000, C530S324000

Reexamination Certificate

active

06870027

ABSTRACT:
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of PUMP-1 protease (matrix metalloprotease 7). The detected proteases are themselves specifically over-expressed in certain cancers, and their presence may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.

REFERENCES:
Bowie et al (Science, 1990,247:1306-1310).*
Akizawa et al (Peptide Chemistry, 1995, 33:305-308).*
Harlow and Lane, (Antibodies, A Laboratory Manual, 1988, Cold Spring Harbor Laboratory, New York, pp. 96-97).

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