Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Patent
1992-12-01
1994-11-15
Schwartz, Richard A.
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
2041801, 2041821, 2041828, 435 4, 435 71, G01N 3349, G01N 33487, G01N 2726, C12Q 100
Patent
active
053647939
ABSTRACT:
Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
REFERENCES:
patent: 3540850 (1970-11-01), Halpaap
patent: 3873433 (1975-03-01), Seidel et al.
patent: 3930983 (1975-01-01), Sieber
patent: 3979507 (1976-09-01), Baker
patent: 4118469 (1978-10-01), Caldwell et al.
patent: 4124470 (1978-11-01), Dahms
patent: 4178285 (1979-12-01), Felts et al.
patent: 4211530 (1980-07-01), Goverde et al.
patent: 4264589 (1981-04-01), Felts et al.
patent: 4311788 (1982-01-01), Heuck et al.
patent: 4416998 (1983-11-01), Adams et al.
patent: 4466951 (1984-08-01), Pittman et al.
patent: 4468466 (1984-08-01), Morrissey
patent: 4558007 (1985-12-01), Anderson et al.
patent: 4579735 (1986-04-01), Heimburger et al.
patent: 4579825 (1986-04-01), Siedel et al.
patent: 4603106 (1986-07-01), Cerami et al.
patent: 4619895 (1986-10-01), Cubicciotti et al.
patent: 4645748 (1987-02-01), Hurwitz et al.
patent: 4648974 (1987-03-01), Rosskopf et al.
patent: 4654301 (1987-03-01), Anderson et al.
patent: 4666578 (1987-05-01), Yamamoto
patent: 4677057 (1987-06-01), Curtiss et al.
patent: 4698298 (1987-10-01), Dedieu et al.
patent: 4708939 (1987-11-01), Siedel et al.
patent: 4722893 (1988-02-01), Shigeta et al.
patent: 4746605 (1988-05-01), Kerscher et al.
patent: 4778768 (1988-10-01), Hein.ang.gard et al.
patent: 4791066 (1988-12-01), Ishiguro
patent: 4820505 (1989-04-01), Ginsberg et al.
patent: 4822776 (1989-04-01), Cerami et al.
patent: 4828986 (1989-05-01), Smith et al.
patent: 4877746 (1989-10-01), Jansson et al.
patent: 4892814 (1990-01-01), Harrington et al.
patent: 4892815 (1990-01-01), Kerscher et al.
patent: 4895558 (1990-01-01), Cham
patent: 4920115 (1990-04-01), Nestler et al.
patent: 4923439 (1990-05-01), Seidel et al.
patent: 4935363 (1990-06-01), Brown et al.
patent: 4943522 (1990-07-01), Eisinger et al.
patent: 4943527 (1990-07-01), Protter et al.
patent: 4945040 (1990-07-01), Fless et al.
patent: 4948723 (1990-08-01), Hermon-Taylor et al.
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 4970144 (1990-11-01), Fareed et al.
patent: 4973638 (1990-11-01), Sparrow et al.
patent: 4975528 (1990-12-01), Kaminski et al.
patent: 4978503 (1990-12-01), Shanks et al.
patent: 4997916 (1991-03-01), Aviv et al.
patent: 5030722 (1991-07-01), Snyder et al.
patent: 5032511 (1991-07-01), Takahashi et al.
patent: 5045480 (1991-09-01), Johnson et al.
patent: 5049488 (1991-09-01), Baer et al.
patent: 5055396 (1991-10-01), Curtiss et al.
patent: 5059528 (1991-10-01), Bollen et al.
patent: 5064769 (1991-11-01), Gambert et al.
Carlsson, et al, Clinica Chimica Acta, "Clinical relevance of the quantification of apolipoprotein E in cerebrospinal fluid", vol. 196, (1991) pp. 167-176.
Basu et al., Proc. Natl. Acad. Sci. USA, vol. 78, No. 12, pp. 7545-7549 Dec., 1981.
Basu et al., Science, vol. 219, Feb., 1983, pp. 871-873.
Boyles et al., J. Clin. Invest, vol. 76, Oct. 1985, pp. 1501-1513.
Boyles et al., J. Clin. Invest, vol. 83, Mar. 1989, pp. 1015-1031.
Boyles et al., J. Biol. Chem., vol. 265, No. 29, Oct., 1990, pp. 17805-17815.
Breslow, Ann. Rev. Biochem. 1985, 54 pp. 699-727.
Cuthbert et al., Proc. Natl. Acad. Sci. USA, vol. 81, pp. 4539-4543, Jul., 1984.
Elshourbagy et al., Proc. Natl. Acad. Sci. USA, vol. 82, pp. 203-207, Jan., 1985.
Folkman et al., Nature, vol. 273, Jun. 1, 1978 pp. 345-349.
Frohlich et al., Clin. Biochem., vol. 22, pp. 51-56, 1989.
Hallman et al., Am. J. Hum. Genet 49 pp. 338-349, 1991.
Kostner, Biochemical Society Transactions, 629th Meeting, London, vol. 17, pp. 639-641.
Lalazar et al., J. Biol. Chem., vol. 264, No. 15, May 25, 1989, pp. 8447-8450.
Mahley, Science, vol. 240, Apr. 1988, pp. 622-630.
Majack et al., J. Cell. Biol., vol. 107, Sep. 1988, pp. 1207-1213.
Menzel et al., Electrophoresis 1986, 7, pp. 492-495.
Muller et al., Journal of Neuroscience Research 18 pp. 222-229 (1987).
Pitas, J. Biol. Chem, vol. 262, No. 29, Oct. 15, 1987, pp. 14352-14360.
Pitas et al., Biochimica et Biophysica Acta 917 (1987) pp. 148-161.
Rall, Jr. et al., J. Clin. Invest., vol. 83, Apr. 1989, pp. 1095-1101.
Roheim et al., Proc. Natl. Acad. Sci. USA, vol. 76, No. 9, pp. 4646-4649, Sep., 1979.
Roheim et al., European Heart Journal (1990) 11 (Supplement E), pp. 225-229.
Ross, The New England Journal of Medicine, vol. 314, No. 8, Feb. 20, 1986, pp. 488-500.
Snipes et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 1130-1134, Feb., 1986, Neurobiology.
Sprecher et al., Clin. Chem. 30/12, pp. 2084-2092 (1984).
Utermann et al., J. Lipid Research, vol. 25, 1984, pp. 378-382.
Weisgraber et al., J. Biol. Chem., vol. 257, No. 5, Mar. 10, 1982, pp. 2518-2521.
Weisgraber et al., Biochemical and Biophysical Research Communications, vol., 157, No. 3, 1988, pp. 1212-1217.
Werb et al., J. Exp. Med., vol. 158, Oct., 1983, pp. 1272-1293.
Wilson et al., Science, vol. 252, Jun. 28, 1991, pp. 1817-1822.
Zannis et al., Biochemistry, vol. 20, No. 4, 1981, pp. 1033-1041.
Zannis et al., J. Lipid Research, vol. 23, 1982, pp. 911-914.
Ahonen et al., Acta Neurologica Scandinavica, vol. 58, Fasc. 6 (1978) 358-365.
Felgenhauer et al., Clinica Chimica Acta, 100 (1980) pp. 121-132.
Frot et al., Marker Proteins in Inflammation, pp. 253-273 (1982).
Harrington et al., Clin. Chem. vol. 30, No. 12, pp. 1933-1937 (1982).
Kushner, Annals of the New York Acad. of Sci., pp. 39-48 (1982).
McCarty, Annals of the New York Acad. of Sci., pp. 1-10 (1982).
Merril et al., Clin. Chem. vol. 28, No. 4, pp. 1015-1020 (1982).
Tracy et al., Clin. Chem. vol. 28, No. 4, pp. 890-899 (1982).
Tracy et al., Clin. Chem. vol. 28, No. 4, pp. 900-907 (1982).
Tracy et al., Clin. Chem. vol. 28, No. 4, pp. 915-919 (1982).
Tracy et al., J. Clin. Laboratory Automation, vol. 3, No. 4, (1983) pp. 235-243.
Varma et al., Experimental Cell Research 173 (1987) pp. 163-173.
Willard et al., Clin. Chem. vol. 28, No. 4, pp. 1067-1073 (1982).
Havel et al., "Lipoproteins and Lipid Transport" in Metabolic Control and Diseases, pp. 393-494 (1980).
Hui et al., J. Biol. Chem., pp. 11775-11781 (1980).
Hochstrasser et al., Applied & Theoretical Electro., pp. 73-76 (1988).
Ignatius et al., Science, vol. 236, pp. 959-962 (1987).
Ignatius et al., PNAS USA, vol. 83, pp. 1125-1129 (1986).
Ignatius et al., Prog in Brain Res., vol. 71, pp. 177-184 (1987).
Cameron, Sr. Bruce M.
Creed Guy J.
Merril Carl R.
VanderPutten Dale
Hodges Robert A.
Monoclonetics International, Inc.
Schwartz Richard A.
The United States of America as represented by the Secretary of
LandOfFree
Methods for the diagnosis of peripheral nerve damage does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for the diagnosis of peripheral nerve damage, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the diagnosis of peripheral nerve damage will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1097174