Methods for the diagnosis of glaucoma

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

5303871, 5303913, 424 149, 4241391, 4241411, 424 934, 4241521, C07K 1618, A61K 3944

Patent

active

058498796

ABSTRACT:
A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.

REFERENCES:
patent: 4617299 (1986-10-01), Knepper
patent: 4757089 (1988-07-01), Epstein
patent: 4829088 (1989-05-01), Doulakas, Jr.
patent: 4886743 (1989-12-01), Hood
patent: 5124154 (1992-06-01), Babcock et al.
patent: 5130238 (1992-07-01), Malek et al.
patent: 5169766 (1992-12-01), Schuster et al.
patent: 5192535 (1993-03-01), Davis et al.
patent: 5420120 (1995-05-01), Boltralik
patent: 5474985 (1995-12-01), Polansky et al.
patent: 5606043 (1997-02-01), Nguyen et al.
Yun et al 1989 Invest, Ophthal, & Visual Science 30:2012.
Chen et al. Invest. Opthalmology and Visual Science 34: Abstract 2264 Mar. 15, 1993.
Polansky, J.R. et al, "Glucocorticoid Receptors and Steroid Glaucoma Mechanisms," In Encounters in Glaucoma Research 1:Receptor Biology amd Glaucoma, Fogliazza Editore, Milan pp. 273-299 (1994).
Polansky, J.R. et al, "Cellular Mechanisms Influencing the Aqueous Outflow Pathway," In: Principles and Practice of Opthalmology, Albert, D.M et al., Eds., .B. Saunders & Co. Philadelphia, pp. 226-251 (1994).
Polansky, J.R., "HTM Cell Culture Model for Steriod Effects on Intraocular Pressue: Overview," In: Schriftenrreihe de Adedemie der Wissenschaften un der Literatur, Mainz, 307-318 (1993).
Nguyen, T. D. et al. "Glucocorticoid (GC) Effects on HTM Cells: Molecular Biology Approaches," In: Schriftenreihe de Adademie der Wissenschaften und der Literatur Mainz, 331-343 (1993).
Polansky, J.R., "Growth Factor Effects and Modulation of Glucocorticoid (GC) and other Stress Responses in Human Trabecular Meshwork (HTM) Cells," Exper. Eye Res. 55:Ab265 (1992).
Clark, A.F., "Evaluation of Anti-Glaucoma Compounds and Discovery of Pathogenic Mechanisms using Perfusion Cultured Human Eyes," Exper. Eye Res. 55:Ab266 (1992).
Vaughan, D. et al. In: General Ophthalmology, Appelton & Lange, Norwalk, CT, pp. 213-230 (1992).
Zhan, G.L. et al., "Steroid Glaucoma: Corticosteroid-Induced Ocular Hypetension in Cats, " Exper. Eye Res. 54:211-218 (1992).
Walker, G. Terrance et al., "Isothermal In Vitro Amplification Of DNA By A Restriction Enzyme/DNA Polymerase System," Proc. Natl. Acad. Sci. USA,, 89:392-396 (1992).
Nguyen, T. D. et al. "Molecular Biology Studies of Steroid-Induced Glaucoma Model using Cultured Human Trabecular Meshwork," Invest Ophthalmol Vis. Sci. 32789 (1991).
Polansky, J.R. et al., "In Vitro Correlates of Glucocorticoid Effects on Intraocular Pressue," In: Glaucoma Update IV, Springer-Verlag, Berlin, pp. 20-29 (1991).
Barany, Francis, "Genetic Disease Detection and DNA Amplification Using Cloned Thermostble Ligase," Proc. Natl. Acad. Sci. USA, 88:189-193 (1991).
Nickerson, Deborah A. et al., "Automated DNA Diganostics Using An Elisa-Based Oligonucleotide Ligation Assay," Proc. Natl. Acad. Sci. USA,, 87:8923-8927 (1990).
Nguyen et al. Cloning of glucocorticoid-induced proteins in HTM cells; verification of progressive, high dose dependent, cDNAs to correlate with effects on IOP, Invest. Opthalmol. Vis Sci. 32:789 (1990).
Fauss et al. "Comparison of Glucocorticoid (GC) Effects and Oxidative Stress on Protein/Glycoprotein Synthesis in Cultured Cells". Invest. Opthamol. Visual Sci. 31(4): 435 (1990).
Yun, A.J. et al., "Proteins Secreted by Human Trabecular Cells," Invest. Ophthalmol. Vis. Sci. 30:2012-2022 (1989).
Polansky, J.R. et al, "Eicosanoid Production and Glucocorticoid Regulatory Mechanisms in Cultured Human Trabecular Meshwork Cels," Prog Clin Biol Res 312:113-138 (1989).
Partridge et al. "Dexamethasone Induces Specific Ptoteins in Human Trabecular Meshwork Cells". Invest. Opthamol. Visual Sci. 30(8): 1843-1847 (1989).
Kwoh, D.Y., et al.)"Transcription-Based Amplification System and Detection of Amplified Human Immunodefiency Virus Type 1 With A Bead-Based Sandwich Hybridization Format," Proc. Acad. Sci. USA, 86:1173-1177 (1989).
Rychlik, Wojciech et al., "A Computer Program For Choosing Optimal Oligonucleotides For Filter Hybridization, Sequencing and In Vitro Amplification of DNA," Nucleic Acids Research, 17:8543-8551 (1989).
Baldino, Frank, Jr., et al., "High-Resolution in Situ Hybridization Histochemistry," Methods in Enzymology, 168:761-777 (1989).
Landegren, Ulf et al., "A Ligase-Mediated Gene Detection Technique, " Science, 241:1017-1080 (1988).
Breslauer, Kenneth J. et al., "Predicting DNA Duplex Stability From The Base Sequence," Proc. Natl. Acad. Sci. USA,, 83:3746-3750 (1986).
Freier, Susan M. et al., "Improved Free-Energy Parameters for Predictions of RNA Duplex Stability," Proc. Natl. Acad. Sci. USA,, 83:9373-9377 (1986).
Wu, Dan Y. et al., "The Litigation Amplification Reaction (LAR)--Amplification of Specific DNA Sequences Using Sequential Rounds of Template-Dependent Ligation," Genomics 4:560-569.
Lathe R., "Synthetic Oligonucleotide Probes Deduced From Amino Acid Sequence Data--Theoretical and Practical Considerations," Journal of Molecular Biology, 183:1-12 (1985).
Weinreb, R.N. et al., Detection of Glucocorticoid Receptors in Cultured Human Trabecular Cells, Invest Ophthalmol. Vis. Sci. 21:403-407 (1981).
Polansky, J.R. et al. "Studies on Human Trabecular Cells Propagated In Vitro," Vision Research 21155-160 (1981).
Schildkraut, Carl et al., "Dependence of the Melting Temperature of DNA on Salt Concentration," Biopolymers, 3:195-208 (1965).
Stone et al., "Identification of a Gene that Causes Primary Open Angle Glaucoma", Science 275:668-670 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for the diagnosis of glaucoma does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the diagnosis of glaucoma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the diagnosis of glaucoma will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1459151

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.