Methods for the diagnosis of glaucoma

Details Methods for the diagnosis of glaucoma Methods for the diagnosis of glaucoma

1998-12-24

2000-11-21

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 4352542, 536 235, C07H 2104, C12N 510

Patent

active

061501611

ABSTRACT:
A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.

REFERENCES:
patent: 4617299 (1986-10-01), Knepper
patent: 4757089 (1988-07-01), Epstein
patent: 4829088 (1989-05-01), Doulakas, Jr.
patent: 4886743 (1989-12-01), Hood
patent: 5124154 (1992-06-01), Babcock et al.
patent: 5130238 (1992-07-01), Malek et al.
patent: 5169766 (1992-12-01), Schuster et al.
patent: 5192535 (1993-03-01), Davis et al.
patent: 5420120 (1995-05-01), Boltralik
patent: 5474985 (1995-12-01), Polansky et al.
patent: 5516657 (1996-05-01), Murphy et al.
patent: 5606043 (1997-02-01), Nguyen et al.
patent: 5789169 (1998-08-01), Nguyen et al.
patent: 5849879 (1998-12-01), Nguyen et al.
patent: 5854415 (1998-12-01), Nguyen et al.
patent: 5861497 (1999-01-01), Nguyen et al.
patent: 5885776 (1999-03-01), Stone et al.
patent: 5916778 (1999-06-01), Stone et al.
patent: 5925748 (1999-07-01), Stone et al.
Baldino, Frank, Jr., et al., "High-Resolution in Situ Hybridization Histochemistry," Methods in Enzymology, 168:761-777 (1989).
Barany, Francis, "Genetic Disease Detection and DNA Amplification Using Cloned Thermostble Ligase," Proc. Natl. Acad. Sci. USA, 88:189-193 (1991).
Breslauer, Kenneth J. et al., "Predicting DNA Duplex Stability From The Base Sequence," Proc. Natl. Acad. Sci. USA,, 83:3746-3750 (1986).
Chen, et al., "Expression of Trabecular Meshwork Inducible Glucocorticoid Response (TIGR) Peptide in SF9 Cells," Inv. Opthal. Vis. Sci. 34(4), 1385 (1993 Abstract).
Clark, A.F., "Evaluation of Anti-Glaucoma Compounds and Discovery of Pathogenic Mechanisms using Perfusion Cultured Human Eyes," Exper. Eye Res. 55Ab266 (1992).
Das, "Overproduction of proteins in E. coli: vectors, hosts and strategies" Methods in Enzymology 182:93-112.
Fauss et al. "Comparisons of Glucocorticoid (GC) Effects and Oxidative Stress on Protein/Glycoprotein Synthesis in Cultured Cells". Invest. Opthamol. Visual Sci. 31(4): 435 (1990).
Freier, Susan M. et al., "Improved Free-Energy Parameters for Predictions of RNA Duplex Stability," Proc. Natl. Acad. Sci. USA,, 83:9373-9377 (1986).
Harlow et al., "Antibodies: A Laboratory Manual" Cold Spring Harbor, pp. 72-81 (1989).
Hopp et al. "Prediction of protein antigenic determinants from amino acid sequences." Proc. Natl. Acad. Sci. USA 78(6):3824-28.
InVitrogen Catalog pp. 33-34, 39-40 (1994).
Kwoh, D.Y., et al., "Transcription-Based Amplification System And Detection of Amplified Human Immunodefiency Virus Type 1 With A Bead-Based Sandwich Hybridization Format," Proc. Natl. Acad. Sci. U.S.A. 86:1173-1177 (1989).
Landegren, Ulf et al., "A Ligase-Mediated Gene Detection Technique," Science, 241:1017-1080 (1988).
Lathe, R., "Synthetic Oligonucleotide Probes Deduced From Amino Acid Sequence Data--Theoretical and Practical Considerations," Journal of Molecular Biology, 183:1-12 (1985).
Nguyen, et al., "Cloning of Glucocorticoid-Induced Proteins in HTM Cells: Verification of Progressive, High, Dose Dependent, cDNAs to correlate with effects on IOP," Invest. Ophthalmol. Vis. Sci. 32:789 (1990).
Nguyen, T. D. et al. "Glucocorticoid (GC) Effects on HTM Cells: Molecular Biology Approaches," In: Schriftenreihe de Adademie der Wissenschaften und der Literatur Mainz, 331-343 (1993).
Nguyen, T. D. et al. "Molecular Biology Studies of Steroid-Induced Glaucoma Model using Cultured Human Trabecular Meshwork," Invest Ophthalmol Vis. Sci. 32789 (1991).
Nickerson, Deborah A. et al., "Automated DNA Diagnostics Using An ELISA-Based Oligonucleotide Ligation Assay," Proc. Natl. Acad. Sci. USA, 87:8923-8927 (1990).
Partridge et al. "Dexamethasone Induces Specific Ptoteins in Human Trabecular Meshwork Cells". Invest. Opthamol. Visual Sci. 30(8): 1843-1847 (1989).
Polansky, J.R. et al, "Cellular Mechanisms Influencing the Aqueous Outflow Pathway," In: Principles and Practice of Opthalmology, Albert, D.M. et al., Eds., .B. Saunders & Co. Philadelphia, pp. 226-251 (1994).
Polansky, J.R. et al, "Eicosanoid Production and Glucocorticoid Regulatory Mechanisms in Cultured Human Trabecular Meshwork Cels," Prog Clin Biol Res 312:113-138 (1989).
Polansky, J.R. et al, "Glucocorticoid Receptors and Steroid Glaucoma Mechanisms," In Encounters in Glaucoma Research 1:Receptor Biology and Glaucoma, Fogliazza Editore, Milan pp. 273-299 (1994).
Polansky, J.R. et al. "Studies on Human Trabecular Cells Propagated In Vitro," Vision Research 21155-160 (1981).
Polansky, J.R. et al., "In Vitro Correlates of Glucocorticoid Effects on Intraocular Pressue," In: Glaucoma Update IV, Springer-Verlag, Berlin, pp. 20-29 (1991).
Polansky, J.R., "Growth Factor Effects and Modulation of Glucocorticoid (GC) and other Stress Responses in Human Trabecular Meshwork (HTM) Cells," Exper. Eye Res. 55:Ab265 (1992).
Polansky, J.R., "HTM Cell Culture Model for Steriod Effects on Intraocular Pressue: Overview," In: Schriftenrreihe de Adedemie der Wissenschaften un der Literatur, Mainz, 307-318 (1993).
Rychlik, Wojciech et al., "A Computer Program For Choosing Optimal Oligonucleotides For Filter Hybridization, Sequencing And In Vitro Amplification Of DNA," Nucleic Acids Research, 17:8543-8551 (1989).
Schildkraut, Carl et al., "Dependence of the Melting Temperature of DNA on Salt Concentration," Biopolymers, 3:195-208 (1965).
Stone et al., "Identification of a Gene that Causes Primary Open Angle Glaucoma", Science 275:668-670 (1997).
Vaughan, D., et al., In: General Ophthalmology, Appelton & Lange, Norwalk, CT, pp. 213-230 (1992).
Walker, G. Terrance et al., "Isothermal In Vitro Amplification Of DNA By A Restriction Enzyme/DNA Polymerase System," Proc. Natl. Acad. Sci. USA, 89:392-396 (1992).
Weinreb, R.N. et al., Detection of Glucocorticoid Receptors in Cultured Human Trabecular Cells, Invest Ophthalmol. Vis. Sci. 21:403-407 (1981).
Wu, Dan Y. et al., "The Ligation Amplification Reaction (LAR) --Amplification Of Specific DNA Sequences Using Sequential Rounds Of Template-Dependent Ligation," Genomics 4:560-569.
Yun, A.J. et al., "Proteins Secreted by Human Trabecular Cells," Invest. Ophthalmol. Vis. Sci. 30:2012-2022 (1989).
Zhan, G.L. et al., "Steroid Glaucoma: Corticosteroid-Induced Ocular Hypertension in Cats," Exper. Eye Res. 54:211-218 (1992).

Affiliated with

Also associated with

Rating

Methods for the diagnosis of glaucoma does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the diagnosis of glaucoma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the diagnosis of glaucoma will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1255614