Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-05-09
1997-01-14
Knode, Marian C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 794, 436518, 436528, 436811, G01N 3353, G01N 33537, G01N 33543
Patent
active
055938469
ABSTRACT:
Soluble .beta.-amyloid peptide (.beta.AP) is measured in biological fluids at very low concentrations, typically in the range from 0.1 ng/ml to 10 ng/ml. The measurement of .beta.AP concentrations in animals or conditioned medium from cultured cells can be used for drug screening, where test compounds are administered to the animals or exposed to the cultured cells and the accumulation of .beta.AP in the animal or culture medium observed. It has been found that elevated levels of .beta.AP in body fluids, such as blood and cerebrospinal fluid, is associated with the presence of a .beta.AP-related condition in a patient, such as Alzheimer's Disease. Methods for diagnosing and monitoring .beta.AP-related conditions comprise measuring the levels of .beta.AP in such body fluids from a patient.
REFERENCES:
patent: 4486530 (1984-12-01), David et al.
patent: 4666829 (1987-05-01), Glenner et al.
patent: 5221607 (1993-06-01), Cordell et al.
Seubert, P., et al. (1993) "Secretion of .beta.-Amyloid Precursor Protein Cleaved at the Amino Terminus of the .beta.-Amyloid Peptide" Nature361:260-263.
Citron, M., et al. (1992) "Mutation of the .beta.-Amyloid Precursor Protein in Familial Alzheimer's Disease Increases .beta.-Protein Production" Nature360:672-674.
Anderson, J.P., et al. (1991) "Exact Cleavage Site of Alzheimer Amyloid Precursor in Neuronal PC-12 Cells" Neuroscience Letters128:126-128.
Wisniewski et al. (1989) Biological Markers of Alzheimer's Disease, Eds. Boller et al. pp. 23-29 Springer-Verlag Berlin Heidelberg.
Kim, K. S. et al. "Detection and Quantitation of Amyloid B-Peptide With 2 Monoclonal Antibodies," (1990) Neuroscience Research Communications, vol. 7, No. 2 pp. 113-122.
van Gool, W. A. et al. "Cerebrospinal Fluid Markers of Alzheimer's Disease", (1991) JAGSvol. 39, pp. 1025-1039.
Price, D. L. et al. "Alzheimer disease and the prion disorders amyloid .beta.-protein and Prion protein amyloidoses", (1993) Proc. Natl. Acad. Aci. USA, vol. 90, pp. 6381-6384.
Dyrks, T. et al. "Generation of .beta.A4 from the amyloid protein precursor and fragments thereof", (1993) FEBS Letters, vol. 335, No. 1, pp. 89-03.
Wisniewski, T. et al. "Alzheimer's Disease and Soluble A.beta.", (1994) Neurobiology of Aging, vol. 15, No. 2, pp. 143-152.
Nakamura, T. et al. "Amyloid .beta. Protein Levels in Cerebrospinal Fluid Are Elevated in Early-Onset Alzheimer's Disease", (1994) Annals of Neurology, vol. 36, No. 6, pp. 903-911.
Carroll, R. T. et al. "An Age-Related Correlation Between Levels of .beta.-Amyloid Precursor Protein and .beta.-Amyloid In Human Cerebrospinal Fluid", (1995) Biochemical and Biophysical Research Communications, vol. 210, No. 2, pp. 345-349.
Harlow and Lane, Antibodies A Laboratory Manual, (Cold Spring Harbor Laboratory), pp. 578-582, 1988.
Bullock et al., "Techniques In Diagnostic Pathology", vol. 2, 1991, Academic Press(London), pp., 100-112.
Boller et al., "Biological Markers of Alzheimer's Disease", 1989, Springer-Verlag(Berlin), pp. 24-29.
Pennisi, "A Molecular Whodunit", Science News, vol. 145, No. 1, Jan. 1, 1994, pp. 8-11.
Haass et al., "Amyloid Beta-peptide is produced by cultured cells during normal metabolism", Nature, vol. 359, Sep. 24, 1992, pp. 322-325.
Seubert et al. "Isolation and Quantification of Scluble Alzheimer's .beta.-Peptide From Biological Fluids", Nature, 359:325-327 (24 Sep. 1992).
McKhann et al. "Clinical Diagnosis of Alzheimer's Disease", Neurology, 34:939-944 (Jul. 1984).
Kirschner et al. "Synthetic Peptide Homologous to .beta. Protein From Alzheimer Disease Forms Amyloid-Like Fibrils in vitro", Proc. Natl. Acad. Sci. USA, 84:6953-6957 (Oct. 1987).
Esch et al, "Cleavage of Amyloid .beta. Peptide During Constitutive Processing of Its Precurser", Science 248:1122-1124 (1 Jun. 1990).
Castano et al. "In Vitro Formation of Amyloid Fibrils From Two Synthetic Peptides of Different Lengths Homologous to Alzheimer's Disease .beta. Protein", Biochem. Biophys. Res. Comm., 141(2):702-789 (Dec. 15, 1986).
Allsup et al, "Immunohistochemical evidence For The Derivative of a Peptide Ligand From The Amyloid .beta.-Protein Precurser of Alzheimer Disease", Proc. Natl. Acad. Sci. USA, 85:2790-2794 (Apr. 1988).
Glenner and Wong (1984) Biochem. Biophys. Res. Comm. 120:885.
Glenner and Wong (1984) Biochem. Biophys. Res. Comm. 122;1131.
Masters et al. (1985) Proc. Natl. Acad. Sci. USA 82:4245.
Selkoe et al. (1986) J. Neurochem. 46:1820.
Joachim et al. (1988) Brain Res. 474:100.
Hilbich et al. (1991) J. Mol. Biol. 218:149.
Barrow and Zagorski (1991) Science 253:179.
Burdick et al. (1992) J. Biol. Chem. 267:546.
Palmert et al. (1989) Proc. Natl. Acad. Sci. USA 86:6338.
Weidemann et al. (1989) Cell 57:115.
Henriksson et al. (1991) J. Neurochem. 56:1037.
Palmert et al. (1990) Neurology 40:1028.
Podlisny et al. (19900 Biochem. Biophys. Res. Commun. 167:1094.
Rumble et al. (1989) N. Engl. J. Med. 320:1446.
Schlossmacher et al. (1992) Neurobiol. Aging 13:421.
Wong et al. (1985) Proc. Natl. Acad. Sci. USA 92:8729.
Selkoe (1986) Neurobiol. Aging 7:425.
Pardridge et al. (1987) Biochem. Biophys. Res. Commun. 145:241.
Joachim et al. (1989) Nature 341:226.
Selkoe et al. (1989) Neurobiol. Aging 10:387.
Wisniewski in "Alzheimer's Desease", ed. Becker et al. p. 206.
Mehta et al. in "Techniques in Diagnostic Pathology", ed. Bullock et al. Acadimic Press, Boston. p. 106.
Wolozin et al. (1986) Science 232:648-650.
Ksiezak-Reding et al. (1988) J. Biol. Chem. 263:7943-7947.
Ueda et al. (1990) J. Neuroscience 10:3295-3304.
Lee et al. (1991) Science 251:675-678.
Schenk Dale B.
Seubert Peter A.
Vigo-Pelfrey Carmen
Athena Neurosciences
Duffy Patricia A.
Eli Lilly and Company
Knode Marian C.
LandOfFree
Methods for the detection of soluble .beta.-amyloid peptide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for the detection of soluble .beta.-amyloid peptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the detection of soluble .beta.-amyloid peptide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1387326