Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1993-11-04
1998-04-28
Adams, Donald E.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
435 78, 436503, 436504, 436518, 436804, G01N 33566, G01N 3353
Patent
active
057443688
ABSTRACT:
This invention is directed to methods and compositions for preventing aggregation of amyloid .beta.-protein (.beta.AP) aggregation. Aggregation of amyloid .beta.-protein is associated with the deposition of amyloid in the brain. Amyloid .beta.-protein-binding compounds such as transthyretin are described which form complexes with .beta.AP and prevent formation of amyloid. This invention also identifies the serine 6 mutation in the TTR gene as predictive of person at risk for developing .beta.AP associated amyloidosis.
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Eisenberg-Grunberg Moises
Goldgaber Dmitry Y.
Schwarzman Alexander L.
Adams Donald E.
Duffy Patricia A.
Research Foundation of State University of New York
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