Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-12-11
2000-02-22
Reeves, Julie
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435344, 436503, 5303877, 5303879, 5303888, 5303897, 4211381, 4211551, 4211741, G01N 33574, C07K 1630, C12P 2108
Patent
active
060279052
ABSTRACT:
The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.
REFERENCES:
patent: 4474893 (1984-10-01), Reading
patent: 4722899 (1988-02-01), Hamaoka et al.
patent: 4775620 (1988-10-01), Cardiff et al.
patent: 4882268 (1989-11-01), Penman et al.
patent: 4885236 (1989-12-01), Penman et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5098890 (1992-03-01), Gerwitz et al.
patent: 5273877 (1993-12-01), Fey et al.
patent: 5350835 (1994-09-01), Gaynor et al.
patent: 5519003 (1996-05-01), Mochly-Rosen et al.
patent: 5547928 (1996-08-01), Wu et al.
patent: 5688511 (1997-11-01), Gaynor et al.
Lebel et al., "Lamin A is not synthesized as a larger precursor polypeptide, " Biochemical and Biophysical Research Communications, 49(2): 417-23 (1987).
Berezney et al., "Identification of nuclear matrix protein", Biochem. Biophys. Res. Commun.60:1410-1417 (1974).
Bidwell et al., "Nuclear Matrix Proteins Distinguish Normal Diploid Osteoblasts from Osteosarcoma Cells", Cancer Resarch, 54:28-32 (1994).
Bidwell et al, "Osteocalcin Gene Promoter Binding Factors are Tissue-Specific Nuclear Matrix Components," Proc. Natl. Acad. Sci. USA 90:3162-3166, 1993.
Brancolini et al., "Change in the Expression of a Nuclear Matrix-Associated Protein is Correlated with Cellular Transfomation," Proc. Natl. Acad. Sci. USA88: 6936-6940 (1991).
Ciejak et al., "Actively Transcribed Genes are Associated with the Nuclear Matix," Nature306: 607-609 (1983).
Donat et al., "Unique Nuclear Matrix Protein Alternations in head and Neck Squamous Cell Carcinomas: Intermediate Biomarker Candidates," Otolaryngol. Head Neck Surg.114: 387-393 (1996).
Fey et al., "The Nuclear Matrix: Defining Structural and Functional Roles," Eukaryotic Gene Expression, 1:127-143 (1991).
Fey et al., "Nulcear Matrix Proteins Reflect Cell Type of Origin in Cultured Human Cells," Proc. Natl. Acad. Sci. USA85:121-125 (1988).
Fisher et al., "cDNA Sequencing of Nuclear Lamins A and C Reveals Primary and Secondary Structural Homology to Intermediate Filament Proteins," Proc. Natl. Acad. Sci. USA83:6450-6454 (1986).
Getzenberg et al., "Bladder Cancer-Associated Nuclear Matrix Proteins," Cancer Res.56:690-694 (1996).
Getzenberg et al., "Identification of Nuclear Matrix Proteins in the Cancer and Normal Rat Prostate," Cancer Res.51:6514-6520 (1991).
Getzenberg et al., "Tissue Matrix: Cell Dynamics And Hormone Action," Endocr. Rev. 11:399-417 (1990).
Getzenberg et al., "Tissue Specificity of the Hormonal Response in Sex Accessory Tissues is Associated with Nuclear Matrix Protein Patterns," Molecular Endocrinology 1336:1342 (1990).
Greenfield et al., "Human Papillomavirus 16 E7 Protein Is Associated with the Nuclear Matrix," Proc. Natl. Acad. Sci. USA 88:11217-11221 (1991).
Honore et al., "Cloning of a cDNA Encoding a Novel Human Nuclear Phosphoprotein Belonging to the WD-40 Family," Gene 151:291-296 (1994).
Keesee et al., "Nuclear Matrix Proteins in Human Colon Cancer," Proc. Natl. Acad. Sci. USA 91:1913-1916 (1994).
Keesee et al., "Utilization of Nuclear Matrix Proteins for Cancer Diagnosis," Critical Reviews in Eukarytoic Gene Expression 6(2&3):189-214 (Jun. 19960.
Khanuja et al., "Nuclear Matrix Proteins in Normal and Breast Cancer Cells", Cancer Research 53:3394-3398 (1993).
Ou et al., "Cloning and Characterization of Novel Cellular Protein, TDP-43, That Binds to Human Immunodeficiency Virus Type 1 TAR DNA Sequence Motifs," J. Virology 69:3584-3596 (1995).
Pillai, R. et al., "Oncogene Expression and Prognosis in Cervica Cancer," Cancer Letters 59:171-175 (1991).
Partin et al., "Nuclear Matrix Protein Patterns in Human Benign Prostatic Hyperplasia and Prostate Cancer," Cancer Research53:744-746 (1993).
Stein et al., "Oligodeoxynucleotides as Inhibitors of Gene Expression: A Review," Cancer Research 48:2659-2668 (1988).
Stuurman et al, "Nuclear Matrix from Cells of Different Origin," Journal of Biological Chemistry 265:5460-5465 (1990).
Troyanovsky et al., "Characterization of the Human Gene Encoding Cytokeratin 17 and its Expression Pattern," European Journal of Cell Biology 59:127-137 (1992).
Wu et al., "Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region," The Journal of Biological Chemistry270:14209-14213 (1995).
News Release; "Matritech Scientists Discover Specific Nuclear Matrix Proteins (NMPs) Associated with Cervical Cancer", Aug. (1996).
Seaver et al., "Monoclonal Antibodies in Industry: More Difficult Than Originally Thought," Genetic Engineering News, 14(14):10 and 21 (1994).
Sevier et al., "Monoclonal Antibodies in Clinical Immunology," Clinical Chemistry, 27(11):1791-1806 (1981).
Chiang et al., "Identification of a Tumor-Associated Antigen in Cervical Carcinoma by Two-Dimensional (Crossed) Immunoelectrophoresis," J. Natl. Cancer Inst., 58(1):43-48 (1977).
Adams et al., "Rapid cDNA Sequencing (Expressed Sequence Tags) From A Directionally Cloned Human Infant Brain cDNA Library," Nature Genetics, 4:373-380(1993).
Nucifora et al., "Involvement of the AMLI Gene in the t(3;21) in Therapy-Related Leukemia and in Chronic Myeloid Leukemia in Blast Crisis," Blood, 81(10):2728-2734 (1993).
Smedts et al., "Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intrepithelial neoplasia," Am. J. Pathology, 140(3):601-612, 1992.
Petrov et al., "The expression of cytokeratin No. 17 in squamous cell cancer of the cervix uteri: an immunohistochemical study of 19 case," Voprosy Onkologii, 38(7):797-805 (1992), Abstract only.
Keesee Susan K.
Obar Robert
Wu Ying-Jye
Matritech, Inc.
Reeves Julie
LandOfFree
Methods for the detection of cervical cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for the detection of cervical cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the detection of cervical cancer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-519558