Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-11-12
1994-11-29
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 15, 435183, 435184, 435814, 436514, 436 63, 436 64, 436813, 5303888, 53038885, G01N 33573, G01N 33574, G01N 3353
Patent
active
053690087
ABSTRACT:
The present invention provides methods for detecting and quantitating BCR-ABL gene products and other abnormal ABL gene products of Ph.sup.1 -positive leukemic cells. The invention further provides methods for determining the relative number of leukemic cells compared with normal ABL cells to assess the tumor burden of a patient. In another aspect, the methods of the present invention can be used to determine a specific phase of leukemia, particularly chronic-phase CML.
REFERENCES:
patent: 4939083 (1990-07-01), Fukuda et al.
Maxwell et al., "Philadelphia Chromosome-positive Cells from Chronic Myelogenous Leukemia Patient," Cancer Res, 47, 1731-1739, 1987.
Schiff-Maker, et al., Journal of Virology, vol. 57, No. 3, pp. 1182-1186, 1986.
Konopka, J. B., et al., Journal of Virology, vol. 51, No. 1, pp. 223-232, 1984.
Heisterkamp et al., Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 306:239-242 (1983).
Groffen et al., Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 36:93-99 (1984).
Wang et al., The mouse c-abl locus: molecular cloning and characterization. Cell 36:349-356 (1984).
Konopka et al., An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity, Cell 37:1035-1042 (1984).
Gale and Canaani, An 8-kilobase abl RNA transcript in chronic myelogenous leukemia. Proc. Natl. Acad. Sci. USA 81:5648-5652 (1984).
Wang and Baltimore, Localization of tyrosine kinase-coding region in v-abl oncogene by the expression of v-abl-encoded proteins in bacteria. J. Biol. Chem. 260(1):64-71 (1985).
Kloetzer et al., The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity. Virology 140:230-238 (1985).
Wang, J., Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein. Mol. Cell. Biol. 5(12):3640-3643 (1985).
Kurzrock et al., A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia. Nature 325:631-635 (1987).
Chan et al., A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Nature 325:635-637 (1987).
Walter et al., Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia. Nature 329:851-853 (1987).
Hermans et al., Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia. Cell 51:33-40 (1987).
Maxwell et al., Analysis of P210.sup.bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromsome-positive cells from chronic myelogenous leukemia patients. Cancer Res. 47:1731-1739 (1987).
Kipreos et al., Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine. Proc. Natl. Acad. Sci. USA 84:1345-1349 (1987).
Clark et al., Expression of a distinctive bcr-abl oncogene in Ph.sup.1 -positive acute lymphocytic leukemia (ALL). Science 239:775-777 (1988).
Gutkind and Robbins, Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation. Proc. Natl. Acad. Sci. USA 86:8783-8787 (1989).
Arlinghaus Ralph B.
Guo Jie O.
Wang Jean Y. J.
Board of Regents , The University of Texas System
Scheiner Toni R.
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