Methods for testing oligonucleotide arrays

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091500, C435S091500, C435S091500, C435S807000

Reexamination Certificate

active

07060443

ABSTRACT:
Methods for testing oligonucleotide arrays are disclosed including methods for testing the efficiency of nucleotide coupling; methods for testing amounts of deprotected oligonucleotides; methods for determining amounts of depurinated oligonucleotides; and methods of detecting the presence of cleavable structural features, such as double-stranded nucleic acids.

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Pease, A.C., et al., “Light-generated Oligonucleotide Arrays for Rapid DNA Sequence Analysis,”Proc. Natl. Acad. Sci. USA, 91:5022-5026 (1994).

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