Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2011-06-14
2011-06-14
Long, Scott (Department: 1633)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C435S025000, C600S300000
Reexamination Certificate
active
07960605
ABSTRACT:
Methods for treating neurological diseases and for testing Caloric Restriction (CR) mimetics or CR mimetic candidates. In one exemplary method, a CR mimetic candidate is administered to a transgenic animal and the effects of the administering are determined; the transgenic animal includes an added gene from another type of animal or a modified gene which is designed to produce a disease or ailment of the another type of animal, and the method seeks to determine whether the CR mimetic candidate improves the disease or ailment. Methods relating to neurological disease and other methods relating to CR mimetic testing are also described.
REFERENCES:
patent: 6406853 (2002-06-01), Spindler
patent: 6470894 (2002-10-01), Hersh et al.
patent: 6569624 (2003-05-01), Weindruch et al.
patent: 6638545 (2003-10-01), Rombi
patent: 2003/0124540 (2003-07-01), Spindler
patent: 2003/0224360 (2003-12-01), Spindler
patent: 2004/0047896 (2004-03-01), Malnoe et al.
patent: 2004/0180003 (2004-09-01), Spindler et al.
patent: 2004/0191775 (2004-09-01), Spindler et al.
patent: 2005/0013776 (2005-01-01), Spindler et al.
patent: 2005/0100617 (2005-05-01), Malnoe et al.
patent: 2005/0266438 (2005-12-01), Spindler et al.
Ingram et al. (Aging Cell. (2006) 5 , pp. 97-108).
Horstink et al. (J Neurol Neurosurg Psychiatry. 2002; 72:276-277).
Liu et al. (PNAS. Feb. 19, 2002; 99(4): 1876-1881).
Weindruch et al. (Journal of Gerontology: Series A, 2001; 56A(Special Issue I):20-33).
Mattson et al. (Mechanisms of Ageing and Dvelopment. 2001; 122: 757-788).
Wood et al. (Nature. Aug. 5, 2004; 430:686-689 and 107).
Mercer et al. (Biochemical Pharmacology. 2005; 69:339-345).
Bastianetto et al. (Frontiers in Bioscience. Sep. 1, 2004; 9: 3447-3452).
Kamat et al. (Journal of Ethnopharmacology. 2000; 71: 425-435).
Parker et al. (Nature Genetics. Apr. 2005; 37(4): 349-350, 355).
Raamsdonk et al. (Drug Discovery Today: Disease Models. 2005; 2(4): 291-297).
Noda et al. (IUBMB Life, Jun. 1997; 42(1): 35-44).
Interpharma-Praha 2001 webpages (3 sheets).
Pendleton et al (Journal of Pharmacology and Experimental Therapeutics. 2002; 200(1): 91-96).
Lee et al. (Life Sciences 2003; 73: 167-179).
“Regrapex-R”, Interpharma's website (http://www.interpharma-praha.com/html/specif—regrapex—r.shtml).
Feany, et al., (Climbing assay), Harvard University,Nature, Mar. 23, 2000, 404 (6776):394-8.
Kanno, T.,et al., “Dysfunction of Mouse Liver Mitochondria Induced by 2,2′-azobis-(2-amidinopropane) Dihydrochloride, a Radical Initiator, In Vitro and In Vivo,”Free Radical Res., Sep. 1994: 21(4) pp. 223-234. PMID: 7827694.
Krahenbuhl, S. et al. “Decreased activities of Ubiquinol: Ferricytochrome c oxidoredactase 9complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin [c-lactam]—induced methylmalonic aciduria.”J Biol Chem.Nov 5, 1991; 266(31):20998-1003.
Kyriazis, M.D. “Calorie Restriction Mimetics” PMID: 15044709 [PubMed—in process].
Liu J., et al. Antioxidant and Free radical scavenging activities ofGastrodia elateB1. andUncaria rhynchophylla(Miq.) Jacks.Neuropharmacology. Dec. 1992; 31 (12): 1287-98. PMID: 1470304.
Liu, et al., “Antioxidant and por-oxidant assay for a new drug GEPC: detected by ESR spectrometry and by protective effects on lipid peroxidation and biomolecule degradation.”Res Commun Chem Pathol Paharmacol.Nov. 1993; 92(2): 151-66. PMID: 8303085.
Liu, et al., “Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects on free radical, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA.”Neuropharmacology.Jul. 1993: 32(7):659-69. PMID: 7689708.
Pendleton R.G., et al., “Effects of Pharmacological Agents Upon a Transgenic Mode of Parkinson's Disease inDrosophila melanogaster” (Climbing assay),J Pharmacol Exp Ther.Jan. 2002: 300 (1):9106.Erratum in J. Pharmacol Exp TerMar. 2002: 300(3):1131. PMID 11752102.
Picklo, M.J., et al., in “Acrolein inhibits respiration in isolation brain mitochondria,”Biochem. Biophys. Acta, Feb. 14, 2001 1535(2), pp. 145-152. PMID: 11342003.
Weindruch, et al. “The Retardation of Aging and Disease by Dietary Restriction”, C.C. Thomas, Springfield, IL, 1988, Charles C. Thomas Pub Ltd (Dec. 1988), ISBN: 0398057967.
Gruber, J., et al., “Evidence for a Trade-off Between Survival and Fitness Caused by Resveratrol Treatment of Caenorhabditis Elegans,” Ann N. Y. Acad. Sci., Apr. 2007, pp. 530-542, 1100. (Abstract).
Loren, Karl, “What is OPC Grape Seed Extract and How Does it Work?” http://www.oralchelation.com/ingred/grapeseedextract.htm, Dec. 21, 2006.
Agrawal, Namita, et al., “Identification of Combinatorial Drug Regimens for Treatment of Huntington's Disease UsingDrosophila,” PNAS, 2005, pp. 3777-3781, 102(10).
Agrawal, Namita, et al., “Identification of Combinatorial Drug Regimens for Treatment of Huntington's Disease UsingDrosophila,” HDAC, http://www.hdac.org/features/article.php?p—articleNumber=132, Feb. 16, 2005.
King, M.T., et al., “Mutagenicity Studies with X-Ray-Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial,Drosophilaand Mammalian Test Systems,” Mutat. Res., Jan. 1979, pp. 33-43, 66(1). (Abstract).
Wolfgang, William J., et al., “Suppression of Huntington's Disease Pathology inDrosophilaby Human Single-Chain Fv Antibodies,” PNAS, Aug. 9, 2005, pp. 11563-11568, 102(32).
Haberman, Allan B., “Therapeutic Strategies in Animal Models: The Case of Alzheimer's Disease,” Genetic Engineering News, Sep. 15, 2004, pp. 28 & 31, 24(16).
Ingram, D.K., “Development of Calorie Restriction Mimetics as a Prolongevity Strategy,” Ann N. Y. Acad. Sci., Jun. 2004, pp. 412-23, 1019. (Abstract).
De Cabo, Rafael, “Laboratory of Experimental Gerontology,” http://www.grc.nia.nih.gov/branches/irp/rdecabo.htm, Mar. 12, 2007.
Baur, J.A., et al., “Resveratrol Improves Health and Survival of Mice on a High-Calorie Diet,” Nature, Nov. 16, 2006, pp. 337-42, 444(7117). (Abstract).
Anisimov, V.N., “Effect of Metformin on Life Span and on the Development of Spontaneous Mammary Tumors in HER-2
eu Transgenic Mice,” Exp. Gerontol., Aug./Sep. 2005, pp. 685-693, 40(8-9). (Abstract).
Lamming, Dudley W., et al., “Small Molecules that Regulate Lifespan: Evidence for Xenohormesis,” Molecular Microbiology, 2004, pp. 1003-1009, 53(4).
Hansen, Barbara Caleen, “Symposium: Calorie Restriction: Effects on Body Compsition, Insulin Signaling and Aging,” the Journal of Nutrition, 2001, pp. 900S-902S.
Marsh, J. Lawrence, et al., “Fly models of Huntington's disease,” Human Molecular Genetics, 2003, pp. R187-R193, 12(2).
BioMaker Pharmaceuticals, Inc.
Blakely , Sokoloff, Taylor & Zafman LLP
Long Scott
LandOfFree
Methods for testing for caloric restriction (CR) mimetics does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for testing for caloric restriction (CR) mimetics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for testing for caloric restriction (CR) mimetics will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2649555