Methods for targeting RNA molecules

Details Methods for targeting RNA molecules Methods for targeting RNA molecules

2006-10-03

2006-10-03

Priebe, Scott D. (Department: 1633)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007800, C435S072000, C536S004100, C514S025000

Reexamination Certificate

active

07115372

ABSTRACT:
Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.

REFERENCES:
patent: 6214545 (2001-04-01), Dong et al.
Hwang, S. et al., “Inhibition of gene expression in human cells through small molecule-RNA interactions”, 1999, PNAS, vol. 96: pp. 12997-13002.
Detering, C. et al., “Validation of Automated Docking Programs for Docking and Database Screening against RNA Drug Targets”, 2004, J. Med. Chem., vol. 47: pp. 4188-4201.
Wilson, W.D., et al., “Targeting RNA with Small Molecules”, 2000, Curr. Med. Chem., vol. 7: pp. 73-98.
Hermann, T., “Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes”, 2000, Angew. Chem. Int. Ed., vol. 39: pp. 1890-1905.
Millington-Ward et al., “Strategemsin vitrofor gene therapies directed to dominant mutations” Human Molecular Genetics 6:1415-1426, 1997.
Shen et al., “Single-nucleotide polymorphisms can cause different structural folds of mRNA” Proc. Natl. Acad. Sci. USA 96:7871-7876, 1999.

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