Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1990-02-05
1991-10-29
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
558 88, 558142, 558217, 560128, 562510, 585351, C07F 940
Patent
active
050618199
ABSTRACT:
Processes for synthesizing novel phosphonate diester compounds of the general formula ##STR1## are disclosed and claimed. The claimed process includes forming a reaction mixture of a C-14 aldehyde and a methylene-bis-phosphonic acid ester, separating a pentadienyl phosphonic acid dialkyl ester intermediate from the reaction mixture, optionally isomerizing the intermediate in the presence of a basic catalyst, and isolating the desired pentadienylphosphonic acid dialkyl ester compound. The isolated phosphonate compounds made according to the processes of the present invention may be employed in synthesizing retinoids such as retinoic acid or carotenoids such as beta-carotene.
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Datlow Philip I.
Loyola University of Chicago
Rizzo Nicholas S.
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