Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-07-18
1999-02-23
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546220, 548539, C07D21140, C07D20700
Patent
active
058745890
ABSTRACT:
Disclosed are methods for synthesizing very large collections of diverse diverse tetramic acids, tetronic acids, pentamic acids, pentonic acids, and derivatives thereof and synthetic compound libraries comprising compounds prepared by such methods.
REFERENCES:
patent: 3299095 (1967-01-01), Harris et al.
patent: 3361626 (1968-01-01), Harris et al.
patent: 3752814 (1973-08-01), Fluckiger et al.
patent: 3752888 (1973-08-01), Fluckiger et al.
patent: 3923790 (1975-12-01), Imanaka et al.
patent: 3929790 (1975-12-01), Leimgruber et al.
patent: 3984559 (1976-10-01), Weinstock
patent: 4522911 (1985-06-01), Clecak et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4694081 (1987-09-01), Miller et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5147875 (1992-09-01), Coates et al.
patent: 5164388 (1992-11-01), De et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5324483 (1994-06-01), Cody et al.
patent: 5475013 (1995-12-01), Talley et al.
patent: 5498732 (1996-03-01), Loffet
Armstrong et al., 1996, Acc. Chem. Res. 29: 123-131 Multiple-component condensation stratgies for combinatorial library synthesis.
Bertho et al., 1991, Tetrahedron Ltrs. 32: 1303-1306 Amino acid flourides: Their preparation and use in peptide synthesis.
Brenner et al. (1992), Proc. Natl. Acad. Sci. USA 89:5381-5383. Encoded combinatorial chemistry.
Burger et al., 1993, J. Fluorine Chem. 65: 149-152 3,3,3-trifluoro-2-isocyanopropionates, new versatile building blcoks for the introduction of trifluoromethyl groups into organic molecules.
Carpino et al. (1990), J. Am. Chem. Soc. 112:9651-9652 ((9-Fluorenylmethyl)oxy)carbonyl (FMOC)) amino acid fluorides.
Chaturvedi et al., 1970, J. Med. Chem. 13: 177-181 Analogs of angiotensis II. I. Solid Phase Synthesis.
Coy et al., 1988, Tetrahedron, 44: 835-841 Solid phase reductive alkylation techniques in analogue peptide bond and side chain modification.
El Marini et al., 1992, Synthesis pp. 1104-1108 Synthesis of enantiomerically pure .beta.-and .gamma.-amino acids from aspartic and glutamic acid derivatives.
Evans et al., 1982, J. Amer. Chem. Soc. 104: 1737-1739 Asymmetric alkylation reactions of chiral imide enolates. A practical approach to the enantioselective synthesis of .alpha.-substituted carboxylic acid derivatives.
Fontenot et al., 1991, Peptide Research, 4: 19-25 A survey of potential problems and qulaity control in peptide synthesis by the flourenylmethocvarbonyl procedure.
Giesemann et al., 1982, J. Chem. Res. (S) pp. 79 Synthesis of chiral .alpha.-isocyano esters and other base-sensitive isocyanides with oxomethylenebis-(3H-Imidazolium)Bis(methanesulphonate), a versatile dehydrating reagent.
Geysen et al., 1987, J. Immunol. Meth. 102: 259-274 Strategies for epitope analysis using peptide synthesis.
Giron-Forest et al., 1979, Analytical Profiles of Drug Substances, 8: 47-81 Bromocriptine methanesulphonate.
Gokel et al, 1971, Isonitrile Chemistry, Ugi, I. ed., Academic Press, NY pp. 145-199 Four-component condensations and related reactions.
Gordon et al., 1995, Bioorganic & Medicinal Chemistry Letters, 5: 47-50 Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library.
Hasumi et al, 1993, J. Antibiotics 46: 1782-1787 Lateritin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Gibberella.
Ho et al., 1993, Peptide Research, 6: 10-12 An improved low racemization solid-phase method for the synthesis of reduced dipeptide (YCH2NH) Bond Isosteres.
Horwell et al. (1993), Bioorganic & Medicinal Chemistry Letters, 3(5):799-802 The Design of a dipeptide library for screening at peptide receptor sites.
Hwang et al., 1983, Biochemistry 22: 4756-4763 Specific receptor sites for 1-O-Alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on rabbit platelet and guinea pig smooth muscle membranes.
Jung and Beck-Sickinger (1992), Angewandte Chemie 31(4):367-486 Multiple peptide synthesis methods and their applications.
Keating et al., 1996, J. Am. Chem. Soc. 118:2574-2583 Postcondensation modifications of Ugi four-condensation products: 1-isocyanocyclohexene as a convertible isocyanide.
Kim et al. (1992), Tetrahedron Asymmetry, 3: 1421-1430 Polymer attached cyclic dipeptides as catalysts for enantioselective cyanohydrin formation.
Kucharczyk et al., 1993, J. Med. Chem., 36: 1654-1661 Tetrapeptide tachykinin antagonists: Synthesis and modulationof the physicochemical and pharmacological properties of a new series of partially cyclic analogs.
Leznoff (1978), Account of Chemical Research, pp. 327-333 The use of insoluble polymer supports in general organic synthesis.
Palom et al., 1993, Tetrahedron Letters, 34: 2195-2198 An acid-labile linker for solid-phase oligoribonucleotide synthesis using Fmoc group for 5'-hydroxyl protection.
Rajappa et al., 1993,Advances in heterocyclic chemistry 57:187-289 Piperazine-2,5-diones and related lactim ethers.
Sammes et al., 1975, Chem. Org. Naturst., 32: 51-118 Naturally occuring 2,5-dioxopiperazines and related compounds.
Scott et al., 1995, Molecular Diversity 1(2): 125-134 Solid phase organic synthesis (SPOS):a novel route to diketopiperazines and diketomorpholines.
Shen et al., Feb. 1985, Proc. Natl. Acad. Sci. USA. 82: 672-676 Characerization of a platelet-activating factor receptor antagonist isolated from haifenteng (piper futokadsura): Specific inhibition of in vitro and in vivo platelet-activating factor-induced effects.
Shih et al., 1990, J. Am. Chem. Soc., 112: 9652-9654 Biosynthesis of 3,6-Dideoxyhexoses: Strereochemical Analysis of the Deprotonation Catalyzed by the Pyriodxamine 5'-Phosphate Dependent Enzyme CDP-4-keto-6-deoxy-D-glucose-3-dehydrase Isolated from Yersinia Pseudotuberculosis.
Shimazaki et al., 1987, Chem Parm. Bull., 35: 3527-3530 Diketopiperazine derivatives, A new series of platelet-activating factor inhibitors.
Shimazaki et al., 1987, J. Med. Chem. 30: 1706-1709 Diketopiperazines as a new class of platelet-activating factor inhibitors.
Shiosaki et al., 1990, Peptides: Chemistry Structure and Biology ESCOM Science Publishers B.V., The Netherlands, pp. 978-980 Toward development of peptidomimetics: Diketopiperazine templates for the Trp-Met segment of CCK-4.
Shiosaki et al., 1993,Bioorganic & Medicinal Chemistry Letters, 3: 855-860 Toward development of peptidomimetics: Diketopiperazine templates for the Trp-met segment of CCK-4.
Williams et al., 1988, Chem Rev., 88: 511-540 Bicyclomycin: Synthetic, Mechanistic, and Biological Studies.
Winitz et al., 1956, J. Amer. Chem. Soc. 78:2423-2430 Studies on diastereoisomeric .alpha.-amino acids and corresponding .alpha.-hydroxy acids. VII. Influence of .beta.-configuration on enzymic susceptibility.
Zuckermann et al., 1992, J. Am. Chem. Soc. 114: 10646-10647 Efficient submonomer solid-phase synthesis.
Jouin, P. et al, J. Chem. Soc. Perkin Trans. I, 1987, p. 1177.
Campbell David A.
Romoff Todd T.
Dahlen Garth M.
Glaxo Wellcome Inc.
Kight John
Stevens Lauren L.
LandOfFree
Methods for synthesizing diverse collections of tetramic acids a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for synthesizing diverse collections of tetramic acids a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for synthesizing diverse collections of tetramic acids a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-308560