Methods for synthesizing diverse collections of pyrrolidine comp

Details Methods for synthesizing diverse collections of pyrrolidine comp Methods for synthesizing diverse collections of pyrrolidine comp

1994-12-12

1996-06-11

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548400, 548406, 548453, 548517, 548518, 548532, 548536, 548541, 548560, 548565, 548566, 548570, 548577, 548537, 530323, 435 792, 436518, C07D20700, C07D20900

Patent

active

055257356

ABSTRACT:
Disclosed are methods for synthesizing very large collections of diverse pyrrolidine compounds and derivatives thereof on solid supports and synthetic compound libraries comprising pyrrolidine groups and derivatives thereof prepared by such methods.

REFERENCES:
patent: 5143854 (1992-09-01), Pirrung et al.
Tsuge et al., 1989, Advances in Heterocyclic Chemistry, 45: pp. 231-349, Recent advances in azomethine ylide chemistry.
Cwirla et al., 1990, P.N.A.S. USA, 87: pp. 6378-6382, Peptides on phage: A vast library of peptides for identifying ligands.
Scott et al., 1990, Science 249: pp. 386-390, Searching for Peptide Ligands with an Epitope Library.
Devlin et al., 1990, Science, 249: pp. 404-406, Random Peptide Libraries: A Source of Specific Protein Binding Molecules.
Ardill et al., 1988, Tetrahedron, 44: pp. 4953-4966, X=Y-ZH systems as potential 1,3-Dipoles. Part 19. Intramolecular cycloadditions of non-stabilised azomethine ylides generated via the decarboxylative route from amino acids.
Dorrity et al., 1988, Tetrahedron, 44: pp. 4941-4952, X=Y-ZH systems as potential 1,3-Dipoles. Part 18. Cycloaddition of 4.pi.-sulphinylaminomethamide species generated from .alpha.-amino acids and .alpha.-amino acid esters by sulphonyl group transfer. X-ray crystal structure of 4-Iso-propyl-7-methyl-3,7-diazobicyclo(3.3.0) octane S-oxide.
Grigg et al., 1989, Tetrahedron, 45: pp. 1723-1746, X=Y-ZH systems as potential 1,3-dipoles. Part 21. Activation of the ZH in imines.
Grigg, 1987, Chem. Soc. Rev., 16: pp. 89-121, Prototropic routes to 1,3- and 1,5-dipoles, and 1,2-ylides: Applications to the synthesis of heterocyclic compounds.
Barr et al., 1989, Tetrahedron Ltrs. 30: pp. 4727-4730, Ti(V) mediated transesterification and regio-and-stereo-specific cycloaddition of imines of .alpha.-amino esters. Reversal of normal regiochemistry.
Allway et al., 1991, Tetrahedron Ltrs., 32: pp. 5817-5820, Chiral Co(II) and Mn(II) catalysts for the 1,3-dipolar cycloaddition reactions of azomethine ylides derived from arylidene imines of glycine.
Barr et al., 1990, Tetrahedron Ltrs., 31: pp. 6569-6572, Metal ion catalysed asymmetric 1,3-dipolar cycloaddition reactions of imnes of .alpha.-amino esters.
Grigg et al., 1980, Tetrahedron Ltrs. 21: pp. 2461-2464, X=Y-ZH systems as potential 1,3-dipoles. The stereochemistry and regiochemistry of cycloaddition reactions of imines of .alpha.-amino-acid esters.
Barr et al., 1988, Tetrahedron, 44: pp. 557-570, X=Y-ZH systems as potential 1,3-dipoles. Part 15. Amine generated azaallyl anions versus metallo-1,3-dipoles in cycloadditions of .alpha.-amino acid esters. Facile regio- and stereo-specific formation of pyrrolidines.
Amornraska et al., 1989, Tetrahedron, 45: 4649-4668, X=H-ZH compounds as potential 1,3-dipoles. Part 24. Preparation and thermal fragmentation of imidazolidines. Influence of metal salts on pyrolidine versus imidazolidine formation.
Armstrong et al., 1985, Tetrahedron, 41: pp. 3547-3558, X=Y-ZH systems as potential 1,3-dipoles-5.
Grigg et al., 1993, Tetrahedron., 49: pp. 8679-8690, Chiral azomethine ylides from homochiral cyclic .alpha.-amino esters. Unusual regiospecific deprotonation of iminium ions.
Grigg et al., 1992, Tetrahedron, 48: pp. 10431-10442, Metallo-azomethine ylides from alphatic aldimines. Facile regio- and stereo-specific cycloddition reactions.
Grigg et al., 1987, Tetrahedron., 43: pp. 5887-5898, X=Y-ZH systems as potential 1,3-dipoles. Part 14. Bronsted and Lewis acid catalysis of cycloadditions of arylidene imines of amino acid esters.
Grigg et al., 1987, J. Chem. Soc. Commun.: pp. 47-51, The decarboxylative route to azomethine ylides. Stereochemistry of 1,3-dipole formation.
Petrillo et al., 1982, Medicinal Research Reviews, 2: pp. 1-41 Angiotensin-converting enzyme inhibitors: medicinal chemistry and biological actions.
Grigg et al., 1983, Tetrahedron Ltrs., 24: pp. 4457-4460, The mechanism of the racemisation of .alpha.-amino acids in the presence of aldehydes.
Aly et al., 1994, Tetrahedron., 50: pp. 895-906, X=Y-ZH compounds as potential 1,3-dipoles. Part 41. Azomethine ylide formation from the reactions of .alpha.-amino acids and esters with alloxan (strecker degradation) and with1-phenyl-3-methylpyrazolin-4,5-dione.
Tsuge et al., 1988, J. Org. Chem., 53: pp. 1384-1391, Lithium bromide/triethylamine induced cycloaddition of N-alkylidene 2-amino esters and amides to electron-deficient olefins with high regio-and stereoselectivity.
Cheung et al., 1973, Biochimica et Biophysica Acta, 293: pp. 451-463, Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of bothrops jararaca.
Ellman, 1959, Archives of Biochemistry and Biophysics, 82: pp. 70-77 Tissue sulfhydryl groups.
Furka et al., 1991, Int. J. Peptide Protein Res., 37: pp. 487-493 General method for rapid synthesis of multicomponent peptide mixtures.
Bull et al., 1985, J. of Biological Chem., 260: pp. 2952-2962, Inhibition of rabbit lung angiotensin-converting enzyme by N alpha-[(S)-1-carboxy-3-phenylpropyl] L-alanyl-L-proline and N alpha-[(S)-carboxy-3-phenylpropyl] L-lysyl-L-proline.
Gallop et al., 1994, J. of Medicinal Chem., 37: pp. 1233-1251, Perspectives of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.
Gordon et al., 1994, J. of Medicinal. Chem., 37: pp. 1385-1401, Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions.
Williams et al., 1992, J. Org. Chem., 57: pp. 6527-6532, Asymetric [1,3]-dipolar cycloaddition reactions: Synthesis of highly substituted proline derivatives.
Cull et al., 1992, P.N.A.S. USA, 89: pp. 1865-1869, Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor.

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