Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving urea or urease
Reexamination Certificate
2005-08-09
2005-08-09
McKenzie, Thomas (Department: 1624)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving urea or urease
C532S001000, C546S157000, C548S309100, C548S332100, C560S024000, C560S033000, C560S148000
Reexamination Certificate
active
06927036
ABSTRACT:
Disclosed is a method for synthesizing 1-(acyloxy)-alkyl derivatives of primary or secondary amine drugs from 1-acyl-alkyl derivatives of primary or secondary amine drugs, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amenable to scale-up. For example, 1-acyl-alkyl derivatives of gabapentin and pregabalin are oxidized to yield 1-(acyloxy)-alkyl derivatives of gabapentin and pregabalin, respectively.
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Bhat Laxminarayan
Gallop Mark A.
Xiang Jia-Ning
Yao Fenmei
Zhou Cindy X.
Dorsey & Whitney LLP
McKenzie Thomas
Singh, Esq. Sunil K.
Xero Port, Inc.
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